A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC

A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC

APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that multiple mutations in APCare associated with a po...

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Bibliographic Details
Main Authors: Michael J. Schell, Mingli Yang, Jamie K. Teer, Fang Yin Lo, Anup Madan, Domenico Coppola, Alvaro N. A. Monteiro, Michael V. Nebozhyn, Binglin Yue, Andrey Loboda, Gabriel A. Bien-Willner, Danielle M. Greenawalt, Timothy J. Yeatman
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/33d97e94867e429f930222ed4bd1a79a
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https://doaj.org/article/33d97e94867e429f930222ed4bd1a79a

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