PRMT5 is essential for B cell development and germinal center dynamics

Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells, yet modulates, in p53-independent manners, the sur...

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Autores principales:	Ludivine C. Litzler, Astrid Zahn, Alexandre P. Meli, Steven Hébert, Anne-Marie Patenaude, Stephen P. Methot, Adrien Sprumont, Thérence Bois, Daisuke Kitamura, Santiago Costantino, Irah L. King, Claudia L. Kleinman, Stéphane Richard, Javier M. Di Noia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33da862d42ce48bf82823c6742c63b37
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spelling	oai:doaj.org-article:33da862d42ce48bf82823c6742c63b372021-12-02T15:36:23ZPRMT5 is essential for B cell development and germinal center dynamics10.1038/s41467-018-07884-62041-1723https://doaj.org/article/33da862d42ce48bf82823c6742c63b372019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07884-6https://doaj.org/toc/2041-1723Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells, yet modulates, in p53-independent manners, the survival and differentiation of mature B cells.Ludivine C. LitzlerAstrid ZahnAlexandre P. MeliSteven HébertAnne-Marie PatenaudeStephen P. MethotAdrien SprumontThérence BoisDaisuke KitamuraSantiago CostantinoIrah L. KingClaudia L. KleinmanStéphane RichardJavier M. Di NoiaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ludivine C. Litzler Astrid Zahn Alexandre P. Meli Steven Hébert Anne-Marie Patenaude Stephen P. Methot Adrien Sprumont Thérence Bois Daisuke Kitamura Santiago Costantino Irah L. King Claudia L. Kleinman Stéphane Richard Javier M. Di Noia PRMT5 is essential for B cell development and germinal center dynamics
description	Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells, yet modulates, in p53-independent manners, the survival and differentiation of mature B cells.
format	article
author	Ludivine C. Litzler Astrid Zahn Alexandre P. Meli Steven Hébert Anne-Marie Patenaude Stephen P. Methot Adrien Sprumont Thérence Bois Daisuke Kitamura Santiago Costantino Irah L. King Claudia L. Kleinman Stéphane Richard Javier M. Di Noia
author_facet	Ludivine C. Litzler Astrid Zahn Alexandre P. Meli Steven Hébert Anne-Marie Patenaude Stephen P. Methot Adrien Sprumont Thérence Bois Daisuke Kitamura Santiago Costantino Irah L. King Claudia L. Kleinman Stéphane Richard Javier M. Di Noia
author_sort	Ludivine C. Litzler
title	PRMT5 is essential for B cell development and germinal center dynamics
title_short	PRMT5 is essential for B cell development and germinal center dynamics
title_full	PRMT5 is essential for B cell development and germinal center dynamics
title_fullStr	PRMT5 is essential for B cell development and germinal center dynamics
title_full_unstemmed	PRMT5 is essential for B cell development and germinal center dynamics
title_sort	prmt5 is essential for b cell development and germinal center dynamics
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/33da862d42ce48bf82823c6742c63b37
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PRMT5 is essential for B cell development and germinal center dynamics

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