Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease

PLA2g6 regulates store-operated Ca2+ entry and is linked to Parkinson’s disease. Here, Zhou et al find faulty PLA2g6-dependent Ca2+signaling in idiopathic PD patients, and show that its impairment triggers autophagic dysfunction and loss of dopaminergic neurons in a new PLA2g6 ex2KO mouse model.

Guardado en:

Detalles Bibliográficos
Autores principales:	Qingde Zhou, Allen Yen, Grzegorz Rymarczyk, Hirohide Asai, Chelsea Trengrove, Nadine Aziz, Michael T. Kirber, Gustavo Mostoslavsky, Tsuneya Ikezu, Benjamin Wolozin, Victoria M. Bolotina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33e1f0f92a0c4245b5c7415b37aee723
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:33e1f0f92a0c4245b5c7415b37aee723
record_format	dspace
spelling	oai:doaj.org-article:33e1f0f92a0c4245b5c7415b37aee7232021-12-02T15:33:47ZImpairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease10.1038/ncomms103322041-1723https://doaj.org/article/33e1f0f92a0c4245b5c7415b37aee7232016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10332https://doaj.org/toc/2041-1723PLA2g6 regulates store-operated Ca2+ entry and is linked to Parkinson’s disease. Here, Zhou et al find faulty PLA2g6-dependent Ca2+signaling in idiopathic PD patients, and show that its impairment triggers autophagic dysfunction and loss of dopaminergic neurons in a new PLA2g6 ex2KO mouse model.Qingde ZhouAllen YenGrzegorz RymarczykHirohide AsaiChelsea TrengroveNadine AzizMichael T. KirberGustavo MostoslavskyTsuneya IkezuBenjamin WolozinVictoria M. BolotinaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingde Zhou Allen Yen Grzegorz Rymarczyk Hirohide Asai Chelsea Trengrove Nadine Aziz Michael T. Kirber Gustavo Mostoslavsky Tsuneya Ikezu Benjamin Wolozin Victoria M. Bolotina Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
description	PLA2g6 regulates store-operated Ca2+ entry and is linked to Parkinson’s disease. Here, Zhou et al find faulty PLA2g6-dependent Ca2+signaling in idiopathic PD patients, and show that its impairment triggers autophagic dysfunction and loss of dopaminergic neurons in a new PLA2g6 ex2KO mouse model.
format	article
author	Qingde Zhou Allen Yen Grzegorz Rymarczyk Hirohide Asai Chelsea Trengrove Nadine Aziz Michael T. Kirber Gustavo Mostoslavsky Tsuneya Ikezu Benjamin Wolozin Victoria M. Bolotina
author_facet	Qingde Zhou Allen Yen Grzegorz Rymarczyk Hirohide Asai Chelsea Trengrove Nadine Aziz Michael T. Kirber Gustavo Mostoslavsky Tsuneya Ikezu Benjamin Wolozin Victoria M. Bolotina
author_sort	Qingde Zhou
title	Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
title_short	Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
title_full	Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
title_fullStr	Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
title_full_unstemmed	Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
title_sort	impairment of park14-dependent ca2+ signalling is a novel determinant of parkinson’s disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/33e1f0f92a0c4245b5c7415b37aee723
work_keys_str_mv	AT qingdezhou impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT allenyen impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT grzegorzrymarczyk impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT hirohideasai impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT chelseatrengrove impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT nadineaziz impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT michaeltkirber impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT gustavomostoslavsky impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT tsuneyaikezu impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT benjaminwolozin impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease AT victoriambolotina impairmentofpark14dependentca2signallingisanoveldeterminantofparkinsonsdisease
_version_	1718387015307755520

Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease

Ejemplares similares