Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

Molecular landscapes of metastatic colorectal cancers (mCRC) have often been restricted to coding regions or low numbers of patients. Here the authors present a whole-genome landscape of 429 mCRC patients, revealing the mutational impact of prior therapies and potential actionable targets.

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Detalles Bibliográficos
Autores principales: Pauline A. J. Mendelaar, Marcel Smid, Job van Riet, Lindsay Angus, Mariette Labots, Neeltje Steeghs, Mathijs P. Hendriks, Geert A. Cirkel, Johan M. van Rooijen, Albert J. Ten Tije, Martijn P. Lolkema, Edwin Cuppen, Stefan Sleijfer, John W. M. Martens, Saskia M. Wilting
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/33e7a2ece0a048d1b3f265617bf55c52
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Sumario:Molecular landscapes of metastatic colorectal cancers (mCRC) have often been restricted to coding regions or low numbers of patients. Here the authors present a whole-genome landscape of 429 mCRC patients, revealing the mutational impact of prior therapies and potential actionable targets.

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