Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

Molecular landscapes of metastatic colorectal cancers (mCRC) have often been restricted to coding regions or low numbers of patients. Here the authors present a whole-genome landscape of 429 mCRC patients, revealing the mutational impact of prior therapies and potential actionable targets.

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Autores principales:	Pauline A. J. Mendelaar, Marcel Smid, Job van Riet, Lindsay Angus, Mariette Labots, Neeltje Steeghs, Mathijs P. Hendriks, Geert A. Cirkel, Johan M. van Rooijen, Albert J. Ten Tije, Martijn P. Lolkema, Edwin Cuppen, Stefan Sleijfer, John W. M. Martens, Saskia M. Wilting
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33e7a2ece0a048d1b3f265617bf55c52
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spelling	oai:doaj.org-article:33e7a2ece0a048d1b3f265617bf55c522021-12-02T13:57:54ZWhole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features10.1038/s41467-020-20887-62041-1723https://doaj.org/article/33e7a2ece0a048d1b3f265617bf55c522021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20887-6https://doaj.org/toc/2041-1723Molecular landscapes of metastatic colorectal cancers (mCRC) have often been restricted to coding regions or low numbers of patients. Here the authors present a whole-genome landscape of 429 mCRC patients, revealing the mutational impact of prior therapies and potential actionable targets.Pauline A. J. MendelaarMarcel SmidJob van RietLindsay AngusMariette LabotsNeeltje SteeghsMathijs P. HendriksGeert A. CirkelJohan M. van RooijenAlbert J. Ten TijeMartijn P. LolkemaEdwin CuppenStefan SleijferJohn W. M. MartensSaskia M. WiltingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pauline A. J. Mendelaar Marcel Smid Job van Riet Lindsay Angus Mariette Labots Neeltje Steeghs Mathijs P. Hendriks Geert A. Cirkel Johan M. van Rooijen Albert J. Ten Tije Martijn P. Lolkema Edwin Cuppen Stefan Sleijfer John W. M. Martens Saskia M. Wilting Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
description	Molecular landscapes of metastatic colorectal cancers (mCRC) have often been restricted to coding regions or low numbers of patients. Here the authors present a whole-genome landscape of 429 mCRC patients, revealing the mutational impact of prior therapies and potential actionable targets.
format	article
author	Pauline A. J. Mendelaar Marcel Smid Job van Riet Lindsay Angus Mariette Labots Neeltje Steeghs Mathijs P. Hendriks Geert A. Cirkel Johan M. van Rooijen Albert J. Ten Tije Martijn P. Lolkema Edwin Cuppen Stefan Sleijfer John W. M. Martens Saskia M. Wilting
author_facet	Pauline A. J. Mendelaar Marcel Smid Job van Riet Lindsay Angus Mariette Labots Neeltje Steeghs Mathijs P. Hendriks Geert A. Cirkel Johan M. van Rooijen Albert J. Ten Tije Martijn P. Lolkema Edwin Cuppen Stefan Sleijfer John W. M. Martens Saskia M. Wilting
author_sort	Pauline A. J. Mendelaar
title	Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
title_short	Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
title_full	Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
title_fullStr	Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
title_full_unstemmed	Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
title_sort	whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/33e7a2ece0a048d1b3f265617bf55c52
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Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

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