Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals

Nunzia Nocerino,1 Andrea Fulgione,1 Marco Iannaccone,1 Laura Tomasetta,1 Flora Ianniello,1 Francesca Martora,1 Marco Lelli,2 Norberto Roveri,2 Federico Capuano,3 Rosanna Capparelli1 1Department of Agriculture Special Biotechnology Center Federico II, CeBIOTEC Biotechnology, University of Naples Fed...

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Autores principales:	Nocerino N, Fulgione A, Iannaccone M, Tomasetta L, Ianniello F, Martora F, Lelli M, Roveri N, Capuano F, Capparelli R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/33eab46c792c4f5196953dfd20c96871
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spelling	oai:doaj.org-article:33eab46c792c4f5196953dfd20c968712021-12-02T07:36:58ZBiological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals1178-2013https://doaj.org/article/33eab46c792c4f5196953dfd20c968712014-03-01T00:00:00Zhttp://www.dovepress.com/biological-activity-of-lactoferrin-functionalized-biomimetic-hydroxyap-a16017https://doaj.org/toc/1178-2013 Nunzia Nocerino,1 Andrea Fulgione,1 Marco Iannaccone,1 Laura Tomasetta,1 Flora Ianniello,1 Francesca Martora,1 Marco Lelli,2 Norberto Roveri,2 Federico Capuano,3 Rosanna Capparelli1 1Department of Agriculture Special Biotechnology Center Federico II, CeBIOTEC Biotechnology, University of Naples Federico II, Naples, 2Department of Chemistry, G Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, 3Department of Food Inspection IZS ME, Naples, Italy Abstract: The emergence of bacterial strains resistant to antibiotics is a general public health problem. Progress in developing new molecules with antimicrobial properties has been made. In this study, we evaluated the biological activity of a hybrid nanocomposite composed of synthetic biomimetic hydroxyapatite surface-functionalized by lactoferrin (LF-HA). We evaluated the antimicrobial, anti-inflammatory, and antioxidant properties of LF-HA and found that the composite was active against both Gram-positive and Gram-negative bacteria, and that it modulated proinflammatory and anti-inflammatory responses and enhanced antioxidant properties as compared with LF alone. These results indicate the possibility of using LF-HA as an antimicrobial system and biomimetic hydroxyapatite as a candidate for innovative biomedical applications. Keywords: lactoferrin, hydroxyapatite nanocrystals, biomimetism, biological activity, drug deliveryNocerino NFulgione AIannaccone MTomasetta LIanniello FMartora FLelli MRoveri NCapuano FCapparelli RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1175-1184 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Nocerino N Fulgione A Iannaccone M Tomasetta L Ianniello F Martora F Lelli M Roveri N Capuano F Capparelli R Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
description	Nunzia Nocerino,1 Andrea Fulgione,1 Marco Iannaccone,1 Laura Tomasetta,1 Flora Ianniello,1 Francesca Martora,1 Marco Lelli,2 Norberto Roveri,2 Federico Capuano,3 Rosanna Capparelli1 1Department of Agriculture Special Biotechnology Center Federico II, CeBIOTEC Biotechnology, University of Naples Federico II, Naples, 2Department of Chemistry, G Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, 3Department of Food Inspection IZS ME, Naples, Italy Abstract: The emergence of bacterial strains resistant to antibiotics is a general public health problem. Progress in developing new molecules with antimicrobial properties has been made. In this study, we evaluated the biological activity of a hybrid nanocomposite composed of synthetic biomimetic hydroxyapatite surface-functionalized by lactoferrin (LF-HA). We evaluated the antimicrobial, anti-inflammatory, and antioxidant properties of LF-HA and found that the composite was active against both Gram-positive and Gram-negative bacteria, and that it modulated proinflammatory and anti-inflammatory responses and enhanced antioxidant properties as compared with LF alone. These results indicate the possibility of using LF-HA as an antimicrobial system and biomimetic hydroxyapatite as a candidate for innovative biomedical applications. Keywords: lactoferrin, hydroxyapatite nanocrystals, biomimetism, biological activity, drug delivery
format	article
author	Nocerino N Fulgione A Iannaccone M Tomasetta L Ianniello F Martora F Lelli M Roveri N Capuano F Capparelli R
author_facet	Nocerino N Fulgione A Iannaccone M Tomasetta L Ianniello F Martora F Lelli M Roveri N Capuano F Capparelli R
author_sort	Nocerino N
title	Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
title_short	Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
title_full	Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
title_fullStr	Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
title_full_unstemmed	Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
title_sort	biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/33eab46c792c4f5196953dfd20c96871
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Biological activity of lactoferrin-functionalized biomimetic hydroxyapatite nanocrystals

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