A tissue-engineered urinary conduit in a porcine urinary diversion model

Abstract The use of an ileal segment is a standard method for urinary diversion after radical cystectomy. Unfortunately, utilization of this method can lead to numerous surgical and metabolic complications. This study aimed to assess the tissue-engineered artificial conduit for urinary diversion in...

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Autores principales:	Arkadiusz Jundziłł, Piotr Kwieciński, Daria Balcerczyk, Tomasz Kloskowski, Dariusz Grzanka, Paulina Antosik, Katarzyna Meger, Marta Pokrywczyńska, Tomasz Drewa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/33f491dd1d5644bb971433e5ca431e1e
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spelling	oai:doaj.org-article:33f491dd1d5644bb971433e5ca431e1e2021-12-02T17:08:23ZA tissue-engineered urinary conduit in a porcine urinary diversion model10.1038/s41598-021-94613-72045-2322https://doaj.org/article/33f491dd1d5644bb971433e5ca431e1e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94613-7https://doaj.org/toc/2045-2322Abstract The use of an ileal segment is a standard method for urinary diversion after radical cystectomy. Unfortunately, utilization of this method can lead to numerous surgical and metabolic complications. This study aimed to assess the tissue-engineered artificial conduit for urinary diversion in a porcine model. Tissue-engineered tubular polypropylene mesh scaffolds were used for the right ureter incontinent urostomy model. Eighteen male pigs were divided into three equal groups: Group 1 (control ureterocutaneostomy), Group 2 (the right ureter-artificial conduit-skin anastomoses), and Group 3 (4 weeks before urostomy reconstruction, the artificial conduit was implanted between abdomen muscles). Follow-up was 6 months. Computed tomography, ultrasound examination, and pyelogram were used to confirm the patency of created diversions. Morphological and histological analyses were used to evaluate the tissue-engineered urinary diversion. All animals survived the experimental procedures and follow-up. The longest average patency was observed in the 3rd Group (15.8 weeks) compared to the 2nd Group (10 weeks) and the 1st Group (5.8 weeks). The implant’s remnants created a retroperitoneal post-inflammation tunnel confirmed by computed tomography and histological evaluation, which constitutes urostomy. The simultaneous urinary diversion using a tissue-engineered scaffold connected directly with the skin is inappropriate for clinical application.Arkadiusz JundziłłPiotr KwiecińskiDaria BalcerczykTomasz KloskowskiDariusz GrzankaPaulina AntosikKatarzyna MegerMarta PokrywczyńskaTomasz DrewaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arkadiusz Jundziłł Piotr Kwieciński Daria Balcerczyk Tomasz Kloskowski Dariusz Grzanka Paulina Antosik Katarzyna Meger Marta Pokrywczyńska Tomasz Drewa A tissue-engineered urinary conduit in a porcine urinary diversion model
description	Abstract The use of an ileal segment is a standard method for urinary diversion after radical cystectomy. Unfortunately, utilization of this method can lead to numerous surgical and metabolic complications. This study aimed to assess the tissue-engineered artificial conduit for urinary diversion in a porcine model. Tissue-engineered tubular polypropylene mesh scaffolds were used for the right ureter incontinent urostomy model. Eighteen male pigs were divided into three equal groups: Group 1 (control ureterocutaneostomy), Group 2 (the right ureter-artificial conduit-skin anastomoses), and Group 3 (4 weeks before urostomy reconstruction, the artificial conduit was implanted between abdomen muscles). Follow-up was 6 months. Computed tomography, ultrasound examination, and pyelogram were used to confirm the patency of created diversions. Morphological and histological analyses were used to evaluate the tissue-engineered urinary diversion. All animals survived the experimental procedures and follow-up. The longest average patency was observed in the 3rd Group (15.8 weeks) compared to the 2nd Group (10 weeks) and the 1st Group (5.8 weeks). The implant’s remnants created a retroperitoneal post-inflammation tunnel confirmed by computed tomography and histological evaluation, which constitutes urostomy. The simultaneous urinary diversion using a tissue-engineered scaffold connected directly with the skin is inappropriate for clinical application.
format	article
author	Arkadiusz Jundziłł Piotr Kwieciński Daria Balcerczyk Tomasz Kloskowski Dariusz Grzanka Paulina Antosik Katarzyna Meger Marta Pokrywczyńska Tomasz Drewa
author_facet	Arkadiusz Jundziłł Piotr Kwieciński Daria Balcerczyk Tomasz Kloskowski Dariusz Grzanka Paulina Antosik Katarzyna Meger Marta Pokrywczyńska Tomasz Drewa
author_sort	Arkadiusz Jundziłł
title	A tissue-engineered urinary conduit in a porcine urinary diversion model
title_short	A tissue-engineered urinary conduit in a porcine urinary diversion model
title_full	A tissue-engineered urinary conduit in a porcine urinary diversion model
title_fullStr	A tissue-engineered urinary conduit in a porcine urinary diversion model
title_full_unstemmed	A tissue-engineered urinary conduit in a porcine urinary diversion model
title_sort	tissue-engineered urinary conduit in a porcine urinary diversion model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/33f491dd1d5644bb971433e5ca431e1e
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A tissue-engineered urinary conduit in a porcine urinary diversion model

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