Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease

Background: Abnormal glutamatergic neurotransmission in the primary motor cortex (M1) contributes to Parkinson's disease (PD) pathophysiology and is related to l-dopa-induced dyskinesia (LID). We previously showed that short-term treatment with safinamide, a monoamine oxidase type-B inhibitor w...

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Autores principales:	Andrea Guerra, Francesco Asci, Alessandro Zampogna, Valentina D'Onofrio, Antonio Suppa, Giovanni Fabbrini, Alfredo Berardelli
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Parkinson's disease Short-interval intracortical facilitation Glutamatergic transmission l-dopa-induced dyskinesias Plasticity Safinamide Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/33f518fe6b4e4d1bb64510dc0c1a2725
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spelling	oai:doaj.org-article:33f518fe6b4e4d1bb64510dc0c1a27252021-11-24T04:27:42ZLong-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease1935-861X10.1016/j.brs.2021.11.016https://doaj.org/article/33f518fe6b4e4d1bb64510dc0c1a27252022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1935861X21008317https://doaj.org/toc/1935-861XBackground: Abnormal glutamatergic neurotransmission in the primary motor cortex (M1) contributes to Parkinson's disease (PD) pathophysiology and is related to l-dopa-induced dyskinesia (LID). We previously showed that short-term treatment with safinamide, a monoamine oxidase type-B inhibitor with anti-glutamatergic properties, improves abnormally enhanced short-interval intracortical facilitation (SICF) in PD patients. Objective: To examine whether a long-term SICF modulation has beneficial effects on clinical measures, including LID severity, and whether these changes parallel improvement in cortical plasticity mechanisms in PD. Methods: We tested SICF in patients with and without LID before (S0) and after short- (14 days - S1) and long-term (12 months - S2) treatment with safinamide 100 mg/day. Possible changes in M1 plasticity were assessed using intermittent theta-burst stimulation (iTBS). Finally, we correlated safinamide-related neurophysiological changes with modifications in clinical scores. Results: SICF was enhanced at S0, and prominently in patients with LID. Safinamide normalized SICF at S1, and this effect persisted at S2. Impaired iTBS-induced plasticity was present at S0 and safinamide restored this alteration at S2. There was a significant correlation between the degree of SICF and the amount of iTBS-induced plasticity at S0 and S2. In patients with LID, the degree of SICF at S0 and S2 correlated with long-term changes in LID severity. Conclusions: Altered SICF contributes to M1 plasticity impairment in PD. Both SICF and M1 plasticity improve after long-term treatment with safinamide. The abnormality in SICF-related glutamatergic circuits plays a role in LID pathophysiology, and its long-term modulation may prevent LID worsening over time.Andrea GuerraFrancesco AsciAlessandro ZampognaValentina D'OnofrioAntonio SuppaGiovanni FabbriniAlfredo BerardelliElsevierarticleParkinson's diseaseShort-interval intracortical facilitationGlutamatergic transmissionl-dopa-induced dyskinesiasPlasticitySafinamideNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Stimulation, Vol 15, Iss 1, Pp 99-108 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson's disease Short-interval intracortical facilitation Glutamatergic transmission l-dopa-induced dyskinesias Plasticity Safinamide Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson's disease Short-interval intracortical facilitation Glutamatergic transmission l-dopa-induced dyskinesias Plasticity Safinamide Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Andrea Guerra Francesco Asci Alessandro Zampogna Valentina D'Onofrio Antonio Suppa Giovanni Fabbrini Alfredo Berardelli Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease
description	Background: Abnormal glutamatergic neurotransmission in the primary motor cortex (M1) contributes to Parkinson's disease (PD) pathophysiology and is related to l-dopa-induced dyskinesia (LID). We previously showed that short-term treatment with safinamide, a monoamine oxidase type-B inhibitor with anti-glutamatergic properties, improves abnormally enhanced short-interval intracortical facilitation (SICF) in PD patients. Objective: To examine whether a long-term SICF modulation has beneficial effects on clinical measures, including LID severity, and whether these changes parallel improvement in cortical plasticity mechanisms in PD. Methods: We tested SICF in patients with and without LID before (S0) and after short- (14 days - S1) and long-term (12 months - S2) treatment with safinamide 100 mg/day. Possible changes in M1 plasticity were assessed using intermittent theta-burst stimulation (iTBS). Finally, we correlated safinamide-related neurophysiological changes with modifications in clinical scores. Results: SICF was enhanced at S0, and prominently in patients with LID. Safinamide normalized SICF at S1, and this effect persisted at S2. Impaired iTBS-induced plasticity was present at S0 and safinamide restored this alteration at S2. There was a significant correlation between the degree of SICF and the amount of iTBS-induced plasticity at S0 and S2. In patients with LID, the degree of SICF at S0 and S2 correlated with long-term changes in LID severity. Conclusions: Altered SICF contributes to M1 plasticity impairment in PD. Both SICF and M1 plasticity improve after long-term treatment with safinamide. The abnormality in SICF-related glutamatergic circuits plays a role in LID pathophysiology, and its long-term modulation may prevent LID worsening over time.
format	article
author	Andrea Guerra Francesco Asci Alessandro Zampogna Valentina D'Onofrio Antonio Suppa Giovanni Fabbrini Alfredo Berardelli
author_facet	Andrea Guerra Francesco Asci Alessandro Zampogna Valentina D'Onofrio Antonio Suppa Giovanni Fabbrini Alfredo Berardelli
author_sort	Andrea Guerra
title	Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease
title_short	Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease
title_full	Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease
title_fullStr	Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease
title_full_unstemmed	Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease
title_sort	long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and l-dopa-induced dyskinesia in parkinson's disease
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/33f518fe6b4e4d1bb64510dc0c1a2725
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Long-term changes in short-interval intracortical facilitation modulate motor cortex plasticity and L-dopa-induced dyskinesia in Parkinson's disease

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