The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation

Total body irradiation is an effective conditioning modality before autologous or allogeneic stem cell transplantation. With the whole body being the radiation target volume, a diverse spectrum of toxicities has been reported. This fact prompted us to investigate the long-term sequelae of this treat...

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Autores principales:	Michael Oertel, Jonas Martel, Jan-Henrik Mikesch, Sergiu Scobioala, Christian Reicherts, Kai Kröger, Georg Lenz, Matthias Stelljes, Hans Theodor Eich
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	survivorship TBI long-term toxicity leukemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/33f837e5df8b4a7ab622189efd5c590e
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spelling	oai:doaj.org-article:33f837e5df8b4a7ab622189efd5c590e2021-11-25T17:02:06ZThe Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation10.3390/cancers132256402072-6694https://doaj.org/article/33f837e5df8b4a7ab622189efd5c590e2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5640https://doaj.org/toc/2072-6694Total body irradiation is an effective conditioning modality before autologous or allogeneic stem cell transplantation. With the whole body being the radiation target volume, a diverse spectrum of toxicities has been reported. This fact prompted us to investigate the long-term sequelae of this treatment concept in a large patient cohort. Overall, 322 patients with acute leukemia or myelodysplastic syndrome with a minimum follow-up of one year were included (the median follow-up in this study was 68 months). Pulmonary, cardiac, ocular, neurological and renal toxicities were observed in 23.9%, 14.0%, 23.6%, 23.9% and 20.2% of all patients, respectively. The majority of these side effects were grades 1 and 2 (64.9–89.2% of all toxicities in the respective categories). The use of 12 Gray total body irradiation resulted in a significant increase in ocular toxicities (<i>p</i> = 0.013) and severe mucositis (<i>p</i> < 0.001). Renal toxicities were influenced by the age at transplantation (relative risk: 1.06, <i>p</i> < 0.001) and disease entity. In summary, total body irradiation triggers a multifaceted, but manageable, toxicity profile. Except for ocular toxicities and mucositis, a 12 Gray regimen did not lead to an increase in long-term side effects.Michael OertelJonas MartelJan-Henrik MikeschSergiu ScobioalaChristian ReichertsKai KrögerGeorg LenzMatthias StelljesHans Theodor EichMDPI AGarticlesurvivorshipTBIlong-term toxicityleukemiaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5640, p 5640 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	survivorship TBI long-term toxicity leukemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	survivorship TBI long-term toxicity leukemia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Michael Oertel Jonas Martel Jan-Henrik Mikesch Sergiu Scobioala Christian Reicherts Kai Kröger Georg Lenz Matthias Stelljes Hans Theodor Eich The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
description	Total body irradiation is an effective conditioning modality before autologous or allogeneic stem cell transplantation. With the whole body being the radiation target volume, a diverse spectrum of toxicities has been reported. This fact prompted us to investigate the long-term sequelae of this treatment concept in a large patient cohort. Overall, 322 patients with acute leukemia or myelodysplastic syndrome with a minimum follow-up of one year were included (the median follow-up in this study was 68 months). Pulmonary, cardiac, ocular, neurological and renal toxicities were observed in 23.9%, 14.0%, 23.6%, 23.9% and 20.2% of all patients, respectively. The majority of these side effects were grades 1 and 2 (64.9–89.2% of all toxicities in the respective categories). The use of 12 Gray total body irradiation resulted in a significant increase in ocular toxicities (<i>p</i> = 0.013) and severe mucositis (<i>p</i> < 0.001). Renal toxicities were influenced by the age at transplantation (relative risk: 1.06, <i>p</i> < 0.001) and disease entity. In summary, total body irradiation triggers a multifaceted, but manageable, toxicity profile. Except for ocular toxicities and mucositis, a 12 Gray regimen did not lead to an increase in long-term side effects.
format	article
author	Michael Oertel Jonas Martel Jan-Henrik Mikesch Sergiu Scobioala Christian Reicherts Kai Kröger Georg Lenz Matthias Stelljes Hans Theodor Eich
author_facet	Michael Oertel Jonas Martel Jan-Henrik Mikesch Sergiu Scobioala Christian Reicherts Kai Kröger Georg Lenz Matthias Stelljes Hans Theodor Eich
author_sort	Michael Oertel
title	The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
title_short	The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
title_full	The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
title_fullStr	The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
title_full_unstemmed	The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
title_sort	burden of survivorship on hematological patients—long-term analysis of toxicities after total body irradiation and allogeneic stem cell transplantation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/33f837e5df8b4a7ab622189efd5c590e
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The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation

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