In vivo Hox binding specificity revealed by systematic changes to a single cis regulatory module

Hox proteins are expressed in partially overlapping regions to inform development along the embryo’s head-tail axis. Here the authors analyse a cis regulatory module directly regulated by seven different Drosophila Hox proteins to uncover how different Hox class proteins differentially control its e...

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Autores principales: Carlos Sánchez-Higueras, Chaitanya Rastogi, Roumen Voutev, Harmen J. Bussemaker, Richard S. Mann, James C.-G. Hombría
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/33fa56c7633f40faac90d12b3fc513f9
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Sumario:Hox proteins are expressed in partially overlapping regions to inform development along the embryo’s head-tail axis. Here the authors analyse a cis regulatory module directly regulated by seven different Drosophila Hox proteins to uncover how different Hox class proteins differentially control its expression.