Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula

We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian Peninsula, publishe...

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Autores principales:	J. Francis Borgio, Alia Saeed Rasdan, Bayan Sonbol, Galyah Alhamid, Noor B. Almandil, Sayed AbdulAzeez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multidrug-resistant bacteria <i>Acinetobacter baumannii</i> <i>Mycobacterium tuberculosis</i> mortality <i>Candida auris</i> Arabian Peninsula Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/33fe2320ccd74a47a256755c3e912884
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spelling	oai:doaj.org-article:33fe2320ccd74a47a256755c3e9128842021-11-25T16:47:26ZEmerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula10.3390/biology101111442079-7737https://doaj.org/article/33fe2320ccd74a47a256755c3e9128842021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1144https://doaj.org/toc/2079-7737We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian Peninsula, published during the last 10 years, were retrieved from PubMed and Scopus. A total of 382 studies were included as per the inclusion and exclusion criteria, as well as the PRISMA guidelines, from a thorough screening of 1705 articles, in order to analyse the emerging status and mortality. The emerging nature of >120 multidrug-resistant (MDR) bacteria and fungi in the Arabian Peninsula is a serious concern that requires continuous monitoring and immediate preventive measures. More than 50% (<i>n</i> = 453) of multidrug-resistant, microbe-associated mortality (<i>n</i> = 871) in the Arabian Peninsula was due to MDR <i>Acinetobacter baumannii, Mycobacterium tuberculosis</i> and <i>Staphylococcus aureus</i> infection. Overall, a 16.51% mortality was reported among MDR-infected patients in the Arabian Peninsula from the 382 articles of this registered systematic review. MDR <i>A. baumannii</i> (5600 isolates) prevailed in all the nine countries of the Arabian Peninsula and was one of the fastest emerging MDR bacteria with the highest mortality (<i>n</i> = 210). A total of 13,087 <i>Mycobacterium tuberculosis</i> isolates were reported in the region. <i>Candida auris</i> (580 strains) is the most prevalent among the MDR fungal pathogen in the Arabian Peninsula, having caused 54 mortalities. Active surveillance, constant monitoring, the development of a candidate vaccine, an early diagnosis of MDR infection, the elimination of multidrug resistance modulators and uninterrupted preventive measures with enhanced data sharing are mandatory to control MDR infection and associated diseases of the Arabian Peninsula. Accurate and rapid detection methods are needed to differentiate MDR strain from other strains of the species. This review summarises the logical relation, prevalence, emerging status and associated mortality of MDR microbes in the Arabian Peninsula.J. Francis BorgioAlia Saeed RasdanBayan SonbolGalyah AlhamidNoor B. AlmandilSayed AbdulAzeezMDPI AGarticlemultidrug-resistant bacteria<i>Acinetobacter baumannii</i><i>Mycobacterium tuberculosis</i>mortality<i>Candida auris</i>Arabian PeninsulaBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1144, p 1144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multidrug-resistant bacteria <i>Acinetobacter baumannii</i> <i>Mycobacterium tuberculosis</i> mortality <i>Candida auris</i> Arabian Peninsula Biology (General) QH301-705.5
spellingShingle	multidrug-resistant bacteria <i>Acinetobacter baumannii</i> <i>Mycobacterium tuberculosis</i> mortality <i>Candida auris</i> Arabian Peninsula Biology (General) QH301-705.5 J. Francis Borgio Alia Saeed Rasdan Bayan Sonbol Galyah Alhamid Noor B. Almandil Sayed AbdulAzeez Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula
description	We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian Peninsula, published during the last 10 years, were retrieved from PubMed and Scopus. A total of 382 studies were included as per the inclusion and exclusion criteria, as well as the PRISMA guidelines, from a thorough screening of 1705 articles, in order to analyse the emerging status and mortality. The emerging nature of >120 multidrug-resistant (MDR) bacteria and fungi in the Arabian Peninsula is a serious concern that requires continuous monitoring and immediate preventive measures. More than 50% (<i>n</i> = 453) of multidrug-resistant, microbe-associated mortality (<i>n</i> = 871) in the Arabian Peninsula was due to MDR <i>Acinetobacter baumannii, Mycobacterium tuberculosis</i> and <i>Staphylococcus aureus</i> infection. Overall, a 16.51% mortality was reported among MDR-infected patients in the Arabian Peninsula from the 382 articles of this registered systematic review. MDR <i>A. baumannii</i> (5600 isolates) prevailed in all the nine countries of the Arabian Peninsula and was one of the fastest emerging MDR bacteria with the highest mortality (<i>n</i> = 210). A total of 13,087 <i>Mycobacterium tuberculosis</i> isolates were reported in the region. <i>Candida auris</i> (580 strains) is the most prevalent among the MDR fungal pathogen in the Arabian Peninsula, having caused 54 mortalities. Active surveillance, constant monitoring, the development of a candidate vaccine, an early diagnosis of MDR infection, the elimination of multidrug resistance modulators and uninterrupted preventive measures with enhanced data sharing are mandatory to control MDR infection and associated diseases of the Arabian Peninsula. Accurate and rapid detection methods are needed to differentiate MDR strain from other strains of the species. This review summarises the logical relation, prevalence, emerging status and associated mortality of MDR microbes in the Arabian Peninsula.
format	article
author	J. Francis Borgio Alia Saeed Rasdan Bayan Sonbol Galyah Alhamid Noor B. Almandil Sayed AbdulAzeez
author_facet	J. Francis Borgio Alia Saeed Rasdan Bayan Sonbol Galyah Alhamid Noor B. Almandil Sayed AbdulAzeez
author_sort	J. Francis Borgio
title	Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula
title_short	Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula
title_full	Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula
title_fullStr	Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula
title_full_unstemmed	Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula
title_sort	emerging status of multidrug-resistant bacteria and fungi in the arabian peninsula
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/33fe2320ccd74a47a256755c3e912884
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Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula

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