Topical Fibronectin Improves Wound Healing of Irradiated Skin
Abstract Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins s...
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Nature Portfolio
2017
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oai:doaj.org-article:33fe97d81b974d99b20a3d8bdb3a7a9d2021-12-02T15:06:19ZTopical Fibronectin Improves Wound Healing of Irradiated Skin10.1038/s41598-017-03614-y2045-2322https://doaj.org/article/33fe97d81b974d99b20a3d8bdb3a7a9d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03614-yhttps://doaj.org/toc/2045-2322Abstract Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.Maxwell B. JohnsonBrandon PangDaniel J. GardnerSolmaz Niknam-BeniaVinaya SoundarajanAthanasios BramosDavid P. PerraultKian BanksGene K. LeeRegina Y. BakerGene H. KimSunju LeeYang ChaiMei ChenWei LiLawrence KwongYoung-Kwon HongAlex K. WongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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DOAJ |
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DOAJ |
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Medicine R Science Q Maxwell B. Johnson Brandon Pang Daniel J. Gardner Solmaz Niknam-Benia Vinaya Soundarajan Athanasios Bramos David P. Perrault Kian Banks Gene K. Lee Regina Y. Baker Gene H. Kim Sunju Lee Yang Chai Mei Chen Wei Li Lawrence Kwong Young-Kwon Hong Alex K. Wong Topical Fibronectin Improves Wound Healing of Irradiated Skin |
| description |
Abstract Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds. |
| format |
article |
| author |
Maxwell B. Johnson Brandon Pang Daniel J. Gardner Solmaz Niknam-Benia Vinaya Soundarajan Athanasios Bramos David P. Perrault Kian Banks Gene K. Lee Regina Y. Baker Gene H. Kim Sunju Lee Yang Chai Mei Chen Wei Li Lawrence Kwong Young-Kwon Hong Alex K. Wong |
| author_facet |
Maxwell B. Johnson Brandon Pang Daniel J. Gardner Solmaz Niknam-Benia Vinaya Soundarajan Athanasios Bramos David P. Perrault Kian Banks Gene K. Lee Regina Y. Baker Gene H. Kim Sunju Lee Yang Chai Mei Chen Wei Li Lawrence Kwong Young-Kwon Hong Alex K. Wong |
| author_sort |
Maxwell B. Johnson |
| title |
Topical Fibronectin Improves Wound Healing of Irradiated Skin |
| title_short |
Topical Fibronectin Improves Wound Healing of Irradiated Skin |
| title_full |
Topical Fibronectin Improves Wound Healing of Irradiated Skin |
| title_fullStr |
Topical Fibronectin Improves Wound Healing of Irradiated Skin |
| title_full_unstemmed |
Topical Fibronectin Improves Wound Healing of Irradiated Skin |
| title_sort |
topical fibronectin improves wound healing of irradiated skin |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/33fe97d81b974d99b20a3d8bdb3a7a9d |
| work_keys_str_mv |
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