Death receptor 6 contributes to autoimmunity in lupus-prone mice

Death receptor 6 contributes to autoimmunity in lupus-prone mice

Germinal centre (GC) reactions are driven by T follicular helper (Tfh) cells and their dysregulation can cause autoimmune disease. Here the authors show that the orphan receptor DR6 is a Tfh cell marker that binds syndecan-1 on GC B cells driving autoimmunity in lupus-prone mice.

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Autores principales: Daisuke Fujikura, Masahiro Ikesue, Tsutomu Endo, Satoko Chiba, Hideaki Higashi, Toshimitsu Uede
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3404813b4b0f4f73bb0e2305f7deb185
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spelling oai:doaj.org-article:3404813b4b0f4f73bb0e2305f7deb1852021-12-02T15:38:41ZDeath receptor 6 contributes to autoimmunity in lupus-prone mice10.1038/ncomms139572041-1723https://doaj.org/article/3404813b4b0f4f73bb0e2305f7deb1852017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13957https://doaj.org/toc/2041-1723Germinal centre (GC) reactions are driven by T follicular helper (Tfh) cells and their dysregulation can cause autoimmune disease. Here the authors show that the orphan receptor DR6 is a Tfh cell marker that binds syndecan-1 on GC B cells driving autoimmunity in lupus-prone mice.Daisuke FujikuraMasahiro IkesueTsutomu EndoSatoko ChibaHideaki HigashiToshimitsu UedeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Daisuke Fujikura
Masahiro Ikesue
Tsutomu Endo
Satoko Chiba
Hideaki Higashi
Toshimitsu Uede
Death receptor 6 contributes to autoimmunity in lupus-prone mice
description Germinal centre (GC) reactions are driven by T follicular helper (Tfh) cells and their dysregulation can cause autoimmune disease. Here the authors show that the orphan receptor DR6 is a Tfh cell marker that binds syndecan-1 on GC B cells driving autoimmunity in lupus-prone mice.
format article
author Daisuke Fujikura
Masahiro Ikesue
Tsutomu Endo
Satoko Chiba
Hideaki Higashi
Toshimitsu Uede
author_facet Daisuke Fujikura
Masahiro Ikesue
Tsutomu Endo
Satoko Chiba
Hideaki Higashi
Toshimitsu Uede
author_sort Daisuke Fujikura
title Death receptor 6 contributes to autoimmunity in lupus-prone mice
title_short Death receptor 6 contributes to autoimmunity in lupus-prone mice
title_full Death receptor 6 contributes to autoimmunity in lupus-prone mice
title_fullStr Death receptor 6 contributes to autoimmunity in lupus-prone mice
title_full_unstemmed Death receptor 6 contributes to autoimmunity in lupus-prone mice
title_sort death receptor 6 contributes to autoimmunity in lupus-prone mice
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3404813b4b0f4f73bb0e2305f7deb185
work_keys_str_mv AT daisukefujikura deathreceptor6contributestoautoimmunityinlupuspronemice
AT masahiroikesue deathreceptor6contributestoautoimmunityinlupuspronemice
AT tsutomuendo deathreceptor6contributestoautoimmunityinlupuspronemice
AT satokochiba deathreceptor6contributestoautoimmunityinlupuspronemice
AT hideakihigashi deathreceptor6contributestoautoimmunityinlupuspronemice
AT toshimitsuuede deathreceptor6contributestoautoimmunityinlupuspronemice
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