Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80
Chromatin mediates transcription and DNA repair. Here, the authors show distinct roles of chromatin remodeler INO80 in expression of YY1-regulated genes and repair of DNA breaks by homologous recombination, a DNA repair pathway important for symmetrically-dividing neural progenitors.
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Nature Portfolio
2020
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oai:doaj.org-article:340883430271499d8929db958f2df6452021-12-02T18:47:00ZSymmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino8010.1038/s41467-020-17551-42041-1723https://doaj.org/article/340883430271499d8929db958f2df6452020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17551-4https://doaj.org/toc/2041-1723Chromatin mediates transcription and DNA repair. Here, the authors show distinct roles of chromatin remodeler INO80 in expression of YY1-regulated genes and repair of DNA breaks by homologous recombination, a DNA repair pathway important for symmetrically-dividing neural progenitors.Jason M. KeilDaniel Z. DoyleAdel QaliehMandy M. LamOwen H. FunkYaman QaliehLei ShiNitesh MohanAlice SorelKenneth Y. KwanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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Science Q Jason M. Keil Daniel Z. Doyle Adel Qalieh Mandy M. Lam Owen H. Funk Yaman Qalieh Lei Shi Nitesh Mohan Alice Sorel Kenneth Y. Kwan Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80 |
description |
Chromatin mediates transcription and DNA repair. Here, the authors show distinct roles of chromatin remodeler INO80 in expression of YY1-regulated genes and repair of DNA breaks by homologous recombination, a DNA repair pathway important for symmetrically-dividing neural progenitors. |
format |
article |
author |
Jason M. Keil Daniel Z. Doyle Adel Qalieh Mandy M. Lam Owen H. Funk Yaman Qalieh Lei Shi Nitesh Mohan Alice Sorel Kenneth Y. Kwan |
author_facet |
Jason M. Keil Daniel Z. Doyle Adel Qalieh Mandy M. Lam Owen H. Funk Yaman Qalieh Lei Shi Nitesh Mohan Alice Sorel Kenneth Y. Kwan |
author_sort |
Jason M. Keil |
title |
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80 |
title_short |
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80 |
title_full |
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80 |
title_fullStr |
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80 |
title_full_unstemmed |
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80 |
title_sort |
symmetric neural progenitor divisions require chromatin-mediated homologous recombination dna repair by ino80 |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/340883430271499d8929db958f2df645 |
work_keys_str_mv |
AT jasonmkeil symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT danielzdoyle symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT adelqalieh symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT mandymlam symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT owenhfunk symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT yamanqalieh symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT leishi symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT niteshmohan symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT alicesorel symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 AT kennethykwan symmetricneuralprogenitordivisionsrequirechromatinmediatedhomologousrecombinationdnarepairbyino80 |
_version_ |
1718377672299511808 |