Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients

Abstract Secondary bacterial infections are a potentially fatal complication of influenza infection. We aimed to define the impact of secondary bacterial infections on the clinical course and mortality in coronavirus disease 2019 (COVID-19) patients by comparison with influenza patients. COVID-19 (n...

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Autores principales:	Noa Shafran, Inbal Shafran, Haim Ben-Zvi, Summer Sofer, Liron Sheena, Ilan Krause, Amir Shlomai, Elad Goldberg, Ella H. Sklan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34091026c1fb4931ad679bf2dd756cc2
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spelling	oai:doaj.org-article:34091026c1fb4931ad679bf2dd756cc22021-12-02T17:40:01ZSecondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients10.1038/s41598-021-92220-02045-2322https://doaj.org/article/34091026c1fb4931ad679bf2dd756cc22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92220-0https://doaj.org/toc/2045-2322Abstract Secondary bacterial infections are a potentially fatal complication of influenza infection. We aimed to define the impact of secondary bacterial infections on the clinical course and mortality in coronavirus disease 2019 (COVID-19) patients by comparison with influenza patients. COVID-19 (n = 642) and influenza (n = 742) patients, admitted to a large tertiary center in Israel and for whom blood or sputum culture had been taken were selected for this study. Bacterial culture results, clinical parameters, and death rates were compared. COVID-19 patients had higher rates of bacterial infections than influenza patients (12.6% vs. 8.7%). Notably, the time from admission to bacterial growth was longer in COVID-19 compared to influenza patients (4 (1–8) vs. 1 (1–3) days). Late infections (> 48 h after admission) with gram-positive bacteria were more common in COVID-19 patients (28% vs. 9.5%). Secondary infection was associated with a higher risk of death in both patient groups 2.7-fold (1.22–5.83) for COVID-19, and 3.09-fold (1.11–7.38) for Influenza). The association with death remained significant upon adjustment to age and clinical parameters in COVID-19 but not in influenza infection. Secondary bacterial infection is a notable complication associated with worse outcomes in COVID-19 than influenza patients. Careful surveillance and prompt antibiotic treatment may benefit selected patients.Noa ShafranInbal ShafranHaim Ben-ZviSummer SoferLiron SheenaIlan KrauseAmir ShlomaiElad GoldbergElla H. SklanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noa Shafran Inbal Shafran Haim Ben-Zvi Summer Sofer Liron Sheena Ilan Krause Amir Shlomai Elad Goldberg Ella H. Sklan Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients
description	Abstract Secondary bacterial infections are a potentially fatal complication of influenza infection. We aimed to define the impact of secondary bacterial infections on the clinical course and mortality in coronavirus disease 2019 (COVID-19) patients by comparison with influenza patients. COVID-19 (n = 642) and influenza (n = 742) patients, admitted to a large tertiary center in Israel and for whom blood or sputum culture had been taken were selected for this study. Bacterial culture results, clinical parameters, and death rates were compared. COVID-19 patients had higher rates of bacterial infections than influenza patients (12.6% vs. 8.7%). Notably, the time from admission to bacterial growth was longer in COVID-19 compared to influenza patients (4 (1–8) vs. 1 (1–3) days). Late infections (> 48 h after admission) with gram-positive bacteria were more common in COVID-19 patients (28% vs. 9.5%). Secondary infection was associated with a higher risk of death in both patient groups 2.7-fold (1.22–5.83) for COVID-19, and 3.09-fold (1.11–7.38) for Influenza). The association with death remained significant upon adjustment to age and clinical parameters in COVID-19 but not in influenza infection. Secondary bacterial infection is a notable complication associated with worse outcomes in COVID-19 than influenza patients. Careful surveillance and prompt antibiotic treatment may benefit selected patients.
format	article
author	Noa Shafran Inbal Shafran Haim Ben-Zvi Summer Sofer Liron Sheena Ilan Krause Amir Shlomai Elad Goldberg Ella H. Sklan
author_facet	Noa Shafran Inbal Shafran Haim Ben-Zvi Summer Sofer Liron Sheena Ilan Krause Amir Shlomai Elad Goldberg Ella H. Sklan
author_sort	Noa Shafran
title	Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients
title_short	Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients
title_full	Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients
title_fullStr	Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients
title_full_unstemmed	Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients
title_sort	secondary bacterial infection in covid-19 patients is a stronger predictor for death compared to influenza patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34091026c1fb4931ad679bf2dd756cc2
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Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients

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