Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome

Abstract Bullous Pemphigoid (BP) is an inflammatory rare autoimmune bullous dermatosis, which outcome cannot be predicted through clinical investigations. Eosinophils are the main immune infiltrated cells in BP. However, the release of Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN),...

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Autores principales:	Delphine Giusti, Gregory Gatouillat, Sébastien Le Jan, Julie Plée, Philippe Bernard, Frank Antonicelli, Bach Nga Pham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3412cd42f2764cabac2d7a9d47000b0d
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spelling	oai:doaj.org-article:3412cd42f2764cabac2d7a9d47000b0d2021-12-02T12:32:45ZEosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome10.1038/s41598-017-04687-52045-2322https://doaj.org/article/3412cd42f2764cabac2d7a9d47000b0d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04687-5https://doaj.org/toc/2045-2322Abstract Bullous Pemphigoid (BP) is an inflammatory rare autoimmune bullous dermatosis, which outcome cannot be predicted through clinical investigations. Eosinophils are the main immune infiltrated cells in BP. However, the release of Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN), and Eosinophil Cationic Protein (ECP) upon eosinophil activation has still not been evaluated with respect to BP development. MBP, EDN and ECP were measured by ELISA in serum (n = 61) and blister fluid (n = 20) of patients with BP at baseline, and in serum after 2 months of treatment (n = 41). Eosinophil activation in BP patients was illustrated at baseline by significantly higher MBP, EDN and ECP serum concentrations as compared with control subjects (n = 20), but without distinction according to disease severity or outcome. EDN and ECP values were even higher in the blister fluids (P < 0.01 and P < 0.05, respectively), whereas MBP values were lower (P < 0.001). ECP serum concentration decreased after 60 days of treatment in BP patients with ongoing remission but not in patients who later relapsed (P < 0.05). A reduction of at least 12.8 ng/mL in ECP concentrations provided a positive predictive value for remission of 81%, showing that ECP serum variation could be a useful biomarker stratifying BP patients at risk of relapse.Delphine GiustiGregory GatouillatSébastien Le JanJulie PléePhilippe BernardFrank AntonicelliBach Nga PhamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Delphine Giusti Gregory Gatouillat Sébastien Le Jan Julie Plée Philippe Bernard Frank Antonicelli Bach Nga Pham Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome
description	Abstract Bullous Pemphigoid (BP) is an inflammatory rare autoimmune bullous dermatosis, which outcome cannot be predicted through clinical investigations. Eosinophils are the main immune infiltrated cells in BP. However, the release of Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN), and Eosinophil Cationic Protein (ECP) upon eosinophil activation has still not been evaluated with respect to BP development. MBP, EDN and ECP were measured by ELISA in serum (n = 61) and blister fluid (n = 20) of patients with BP at baseline, and in serum after 2 months of treatment (n = 41). Eosinophil activation in BP patients was illustrated at baseline by significantly higher MBP, EDN and ECP serum concentrations as compared with control subjects (n = 20), but without distinction according to disease severity or outcome. EDN and ECP values were even higher in the blister fluids (P < 0.01 and P < 0.05, respectively), whereas MBP values were lower (P < 0.001). ECP serum concentration decreased after 60 days of treatment in BP patients with ongoing remission but not in patients who later relapsed (P < 0.05). A reduction of at least 12.8 ng/mL in ECP concentrations provided a positive predictive value for remission of 81%, showing that ECP serum variation could be a useful biomarker stratifying BP patients at risk of relapse.
format	article
author	Delphine Giusti Gregory Gatouillat Sébastien Le Jan Julie Plée Philippe Bernard Frank Antonicelli Bach Nga Pham
author_facet	Delphine Giusti Gregory Gatouillat Sébastien Le Jan Julie Plée Philippe Bernard Frank Antonicelli Bach Nga Pham
author_sort	Delphine Giusti
title	Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome
title_short	Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome
title_full	Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome
title_fullStr	Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome
title_full_unstemmed	Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome
title_sort	eosinophil cationic protein (ecp), a predictive marker of bullous pemphigoid severity and outcome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3412cd42f2764cabac2d7a9d47000b0d
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Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome

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