Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.

Signals related to fear memory and extinction are processed within brain pathways involving the lateral amygdala (LA) for formation of aversive stimulus associations, the CA1 area of the hippocampus for context-dependent modulation of these associations, and the infralimbic region of the medial pref...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jörg Lesting, Rajeevan T Narayanan, Christian Kluge, Susan Sangha, Thomas Seidenbecher, Hans-Christian Pape
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3416173d3b434fc7ac772600f0dc75ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3416173d3b434fc7ac772600f0dc75ce
record_format	dspace
spelling	oai:doaj.org-article:3416173d3b434fc7ac772600f0dc75ce2021-11-18T06:51:03ZPatterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.1932-620310.1371/journal.pone.0021714https://doaj.org/article/3416173d3b434fc7ac772600f0dc75ce2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738775/?tool=EBIhttps://doaj.org/toc/1932-6203Signals related to fear memory and extinction are processed within brain pathways involving the lateral amygdala (LA) for formation of aversive stimulus associations, the CA1 area of the hippocampus for context-dependent modulation of these associations, and the infralimbic region of the medial prefrontal cortex (mPFC) for extinction processes. While many studies have addressed the contribution of each of these modules individually, little is known about their interactions and how they function as an integrated system. Here we show, by combining multiple site local field potential (LFP) and unit recordings in freely behaving mice in a fear conditioning paradigm, that theta oscillations may provide a means for temporally and functionally connecting these modules. Theta oscillations occurred with high specificity in the CA1-LA-mPFC network. Theta coupling increased between all areas during retrieval of conditioned fear, and declined during extinction learning. During extinction recall, theta coupling partly rebounded in LA-mPFC and CA1-mPFC, and remained at a low level in CA1-LA. Interfering with theta coupling through local electrical microstimulation in CA1-LA affected conditioned fear and extinction recall depending on theta phase. These results support the hypothesis that theta coupling provides a means for inter-areal coordination in conditioned behavioral responsiveness. More specifically, theta oscillations seem to contribute to a population code indicating conditioned stimuli during recall of fear memory before and after extinction.Jörg LestingRajeevan T NarayananChristian KlugeSusan SanghaThomas SeidenbecherHans-Christian PapePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21714 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jörg Lesting Rajeevan T Narayanan Christian Kluge Susan Sangha Thomas Seidenbecher Hans-Christian Pape Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.
description	Signals related to fear memory and extinction are processed within brain pathways involving the lateral amygdala (LA) for formation of aversive stimulus associations, the CA1 area of the hippocampus for context-dependent modulation of these associations, and the infralimbic region of the medial prefrontal cortex (mPFC) for extinction processes. While many studies have addressed the contribution of each of these modules individually, little is known about their interactions and how they function as an integrated system. Here we show, by combining multiple site local field potential (LFP) and unit recordings in freely behaving mice in a fear conditioning paradigm, that theta oscillations may provide a means for temporally and functionally connecting these modules. Theta oscillations occurred with high specificity in the CA1-LA-mPFC network. Theta coupling increased between all areas during retrieval of conditioned fear, and declined during extinction learning. During extinction recall, theta coupling partly rebounded in LA-mPFC and CA1-mPFC, and remained at a low level in CA1-LA. Interfering with theta coupling through local electrical microstimulation in CA1-LA affected conditioned fear and extinction recall depending on theta phase. These results support the hypothesis that theta coupling provides a means for inter-areal coordination in conditioned behavioral responsiveness. More specifically, theta oscillations seem to contribute to a population code indicating conditioned stimuli during recall of fear memory before and after extinction.
format	article
author	Jörg Lesting Rajeevan T Narayanan Christian Kluge Susan Sangha Thomas Seidenbecher Hans-Christian Pape
author_facet	Jörg Lesting Rajeevan T Narayanan Christian Kluge Susan Sangha Thomas Seidenbecher Hans-Christian Pape
author_sort	Jörg Lesting
title	Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.
title_short	Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.
title_full	Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.
title_fullStr	Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.
title_full_unstemmed	Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.
title_sort	patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/3416173d3b434fc7ac772600f0dc75ce
work_keys_str_mv	AT jorglesting patternsofcoupledthetaactivityinamygdalahippocampalprefrontalcorticalcircuitsduringfearextinction AT rajeevantnarayanan patternsofcoupledthetaactivityinamygdalahippocampalprefrontalcorticalcircuitsduringfearextinction AT christiankluge patternsofcoupledthetaactivityinamygdalahippocampalprefrontalcorticalcircuitsduringfearextinction AT susansangha patternsofcoupledthetaactivityinamygdalahippocampalprefrontalcorticalcircuitsduringfearextinction AT thomasseidenbecher patternsofcoupledthetaactivityinamygdalahippocampalprefrontalcorticalcircuitsduringfearextinction AT hanschristianpape patternsofcoupledthetaactivityinamygdalahippocampalprefrontalcorticalcircuitsduringfearextinction
_version_	1718424283193016320

Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction.

Ejemplares similares