Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT

Abstract Background Detection of pulmonary nodules in MRI requires fast imaging strategies without respiratory motion impairment, such as single-breath-hold Cartesian VIBE. As patients with pulmonary diseases have limited breath-hold capacities, this study investigates the clinical feasibility of no...

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Autores principales:	Susann-Cathrin Olthof, Christian Reinert, Konstantin Nikolaou, Christina Pfannenberg, Sergios Gatidis, Thomas Benkert, Thomas Küstner, Patrick Krumm
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Spiral VIBE Ultrashort echo time MR lung nodule detection Tomography (X-ray computed) Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/3419100de1694b138c42e7f871ee11da
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spelling	oai:doaj.org-article:3419100de1694b138c42e7f871ee11da2021-11-28T12:08:48ZDetection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT10.1186/s13244-021-01124-01869-4101https://doaj.org/article/3419100de1694b138c42e7f871ee11da2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13244-021-01124-0https://doaj.org/toc/1869-4101Abstract Background Detection of pulmonary nodules in MRI requires fast imaging strategies without respiratory motion impairment, such as single-breath-hold Cartesian VIBE. As patients with pulmonary diseases have limited breath-hold capacities, this study investigates the clinical feasibility of non-Cartesian Spiral VIBE under free-breathing compared to CT as the gold standard. Methods Prospective analysis of 27 oncological patients examined in PET/CT and PET/MR. A novel motion-robust 3D ultrashort-echo-time (UTE) MR sequence was evaluated in comparison with CT and conventional breath-hold MR. CT scans were performed under breath-hold in end-expiratory and end-inspiratory position (CT ex, CT in). MR data was acquired with non-contrast-enhanced breath-hold Cartesian VIBE followed by a free-breathing 3D UTE Spiral VIBE. Impact of respiratory motion on pulmonary evaluation was investigated by two readers in Cartesian VIBE, followed by UTE Spiral VIBE and CT ex and the reference standard of CT in. Diagnostic accuracy was calculated, and visual image quality assessed. Results Higher detection rate and sensitivity of pulmonary nodules in free-breathing UTE Spiral VIBE in comparison with breath-hold Cartesian VIBE were found for lesions > 10 mm (UTE Spiral VIBE/VIBE/CT ex): 93%/54%/100%; Lesions 5–10 mm: 67%/25%/ 92%; Lesions < 5 mm: 11%/11%/78%. Lobe-based analysis revealed sensitivities and specificities of 64%/96%/41% and 96%/93%/100% for UTE Spiral VIBE/VIBE/CT ex. Conclusion Free-breathing UTE Spiral VIBE indicates higher sensitivity for detection of pulmonary nodules than breath-hold Cartesian VIBE and is a promising but time-consuming approach. However, sensitivity and specificity of inspiratory CT remain superior in comparison and should be preferred for detection of pulmonary lesions.Susann-Cathrin OlthofChristian ReinertKonstantin NikolaouChristina PfannenbergSergios GatidisThomas BenkertThomas KüstnerPatrick KrummSpringerOpenarticleSpiral VIBEUltrashort echo timeMR lung nodule detectionTomography (X-ray computed)Medical physics. Medical radiology. Nuclear medicineR895-920ENInsights into Imaging, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spiral VIBE Ultrashort echo time MR lung nodule detection Tomography (X-ray computed) Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Spiral VIBE Ultrashort echo time MR lung nodule detection Tomography (X-ray computed) Medical physics. Medical radiology. Nuclear medicine R895-920 Susann-Cathrin Olthof Christian Reinert Konstantin Nikolaou Christina Pfannenberg Sergios Gatidis Thomas Benkert Thomas Küstner Patrick Krumm Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT
description	Abstract Background Detection of pulmonary nodules in MRI requires fast imaging strategies without respiratory motion impairment, such as single-breath-hold Cartesian VIBE. As patients with pulmonary diseases have limited breath-hold capacities, this study investigates the clinical feasibility of non-Cartesian Spiral VIBE under free-breathing compared to CT as the gold standard. Methods Prospective analysis of 27 oncological patients examined in PET/CT and PET/MR. A novel motion-robust 3D ultrashort-echo-time (UTE) MR sequence was evaluated in comparison with CT and conventional breath-hold MR. CT scans were performed under breath-hold in end-expiratory and end-inspiratory position (CT ex, CT in). MR data was acquired with non-contrast-enhanced breath-hold Cartesian VIBE followed by a free-breathing 3D UTE Spiral VIBE. Impact of respiratory motion on pulmonary evaluation was investigated by two readers in Cartesian VIBE, followed by UTE Spiral VIBE and CT ex and the reference standard of CT in. Diagnostic accuracy was calculated, and visual image quality assessed. Results Higher detection rate and sensitivity of pulmonary nodules in free-breathing UTE Spiral VIBE in comparison with breath-hold Cartesian VIBE were found for lesions > 10 mm (UTE Spiral VIBE/VIBE/CT ex): 93%/54%/100%; Lesions 5–10 mm: 67%/25%/ 92%; Lesions < 5 mm: 11%/11%/78%. Lobe-based analysis revealed sensitivities and specificities of 64%/96%/41% and 96%/93%/100% for UTE Spiral VIBE/VIBE/CT ex. Conclusion Free-breathing UTE Spiral VIBE indicates higher sensitivity for detection of pulmonary nodules than breath-hold Cartesian VIBE and is a promising but time-consuming approach. However, sensitivity and specificity of inspiratory CT remain superior in comparison and should be preferred for detection of pulmonary lesions.
format	article
author	Susann-Cathrin Olthof Christian Reinert Konstantin Nikolaou Christina Pfannenberg Sergios Gatidis Thomas Benkert Thomas Küstner Patrick Krumm
author_facet	Susann-Cathrin Olthof Christian Reinert Konstantin Nikolaou Christina Pfannenberg Sergios Gatidis Thomas Benkert Thomas Küstner Patrick Krumm
author_sort	Susann-Cathrin Olthof
title	Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT
title_short	Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT
title_full	Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT
title_fullStr	Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT
title_full_unstemmed	Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT
title_sort	detection of lung lesions in breath-hold vibe and free-breathing spiral vibe mri compared to ct
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/3419100de1694b138c42e7f871ee11da
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Detection of lung lesions in breath-hold VIBE and free-breathing Spiral VIBE MRI compared to CT

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