The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation of DNA damage in breast cancer.

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Autores principales:	Gabriel J. Starrett, Elizabeth M. Luengas, Jennifer L. McCann, Diako Ebrahimi, Nuri A. Temiz, Robin P. Love, Yuqing Feng, Madison B. Adolph, Linda Chelico, Emily K. Law, Michael A. Carpenter, Reuben S Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/341af74da85247c89f420036391ce4bf
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spelling	oai:doaj.org-article:341af74da85247c89f420036391ce4bf2021-12-02T16:57:40ZThe DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis10.1038/ncomms129182041-1723https://doaj.org/article/341af74da85247c89f420036391ce4bf2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12918https://doaj.org/toc/2041-1723The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation of DNA damage in breast cancer.Gabriel J. StarrettElizabeth M. LuengasJennifer L. McCannDiako EbrahimiNuri A. TemizRobin P. LoveYuqing FengMadison B. AdolphLinda ChelicoEmily K. LawMichael A. CarpenterReuben S HarrisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriel J. Starrett Elizabeth M. Luengas Jennifer L. McCann Diako Ebrahimi Nuri A. Temiz Robin P. Love Yuqing Feng Madison B. Adolph Linda Chelico Emily K. Law Michael A. Carpenter Reuben S Harris The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
description	The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation of DNA damage in breast cancer.
format	article
author	Gabriel J. Starrett Elizabeth M. Luengas Jennifer L. McCann Diako Ebrahimi Nuri A. Temiz Robin P. Love Yuqing Feng Madison B. Adolph Linda Chelico Emily K. Law Michael A. Carpenter Reuben S Harris
author_facet	Gabriel J. Starrett Elizabeth M. Luengas Jennifer L. McCann Diako Ebrahimi Nuri A. Temiz Robin P. Love Yuqing Feng Madison B. Adolph Linda Chelico Emily K. Law Michael A. Carpenter Reuben S Harris
author_sort	Gabriel J. Starrett
title	The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
title_short	The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
title_full	The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
title_fullStr	The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
title_full_unstemmed	The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
title_sort	dna cytosine deaminase apobec3h haplotype i likely contributes to breast and lung cancer mutagenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/341af74da85247c89f420036391ce4bf
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The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

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