Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

The impact of intratumour heterogeneity on immune surveillance and clinical outcomes has not been adequately explored in malignant pleural mesothelioma (MPM). Here the authors analyse the influence of evolution on the survival and immune landscape of MPM patients using multi-region sequencing data.

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Autores principales: Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G. Dawson, Apostolos Nakas, Sara Busacca, Annabel J. Sharkey, David Waller, Michael T. Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y. Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martison, Jacqui A. Shaw, Catrin Pritchard, Tamihiro Kamata, Nathaniel Kuse, Lee Brannan, Pan De Philip Zhang, Hongji Yang, Gareth Griffiths, Gareth Wilson, Charles Swanton, Frank Dudbridge, Edward J. Hollox, Dean A. Fennell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/341b50055bdd45939a6f7909af185de3
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spelling oai:doaj.org-article:341b50055bdd45939a6f7909af185de32021-12-02T16:30:42ZClonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment10.1038/s41467-021-21798-w2041-1723https://doaj.org/article/341b50055bdd45939a6f7909af185de32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21798-whttps://doaj.org/toc/2041-1723The impact of intratumour heterogeneity on immune surveillance and clinical outcomes has not been adequately explored in malignant pleural mesothelioma (MPM). Here the authors analyse the influence of evolution on the survival and immune landscape of MPM patients using multi-region sequencing data.Min ZhangJin-Li LuoQianqian SunJames HarberAlan G. DawsonApostolos NakasSara BusaccaAnnabel J. SharkeyDavid WallerMichael T. SheaffCathy RichardsPeter Wells-JordanAarti GabaCharlotte PoileEssa Y. BaiteiAleksandra BzuraJoanna DzialoMaymun JamaJohn Le QuesneAmrita BajajLuke MartisonJacqui A. ShawCatrin PritchardTamihiro KamataNathaniel KuseLee BrannanPan De Philip ZhangHongji YangGareth GriffithsGareth WilsonCharles SwantonFrank DudbridgeEdward J. HolloxDean A. FennellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Min Zhang
Jin-Li Luo
Qianqian Sun
James Harber
Alan G. Dawson
Apostolos Nakas
Sara Busacca
Annabel J. Sharkey
David Waller
Michael T. Sheaff
Cathy Richards
Peter Wells-Jordan
Aarti Gaba
Charlotte Poile
Essa Y. Baitei
Aleksandra Bzura
Joanna Dzialo
Maymun Jama
John Le Quesne
Amrita Bajaj
Luke Martison
Jacqui A. Shaw
Catrin Pritchard
Tamihiro Kamata
Nathaniel Kuse
Lee Brannan
Pan De Philip Zhang
Hongji Yang
Gareth Griffiths
Gareth Wilson
Charles Swanton
Frank Dudbridge
Edward J. Hollox
Dean A. Fennell
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
description The impact of intratumour heterogeneity on immune surveillance and clinical outcomes has not been adequately explored in malignant pleural mesothelioma (MPM). Here the authors analyse the influence of evolution on the survival and immune landscape of MPM patients using multi-region sequencing data.
format article
author Min Zhang
Jin-Li Luo
Qianqian Sun
James Harber
Alan G. Dawson
Apostolos Nakas
Sara Busacca
Annabel J. Sharkey
David Waller
Michael T. Sheaff
Cathy Richards
Peter Wells-Jordan
Aarti Gaba
Charlotte Poile
Essa Y. Baitei
Aleksandra Bzura
Joanna Dzialo
Maymun Jama
John Le Quesne
Amrita Bajaj
Luke Martison
Jacqui A. Shaw
Catrin Pritchard
Tamihiro Kamata
Nathaniel Kuse
Lee Brannan
Pan De Philip Zhang
Hongji Yang
Gareth Griffiths
Gareth Wilson
Charles Swanton
Frank Dudbridge
Edward J. Hollox
Dean A. Fennell
author_facet Min Zhang
Jin-Li Luo
Qianqian Sun
James Harber
Alan G. Dawson
Apostolos Nakas
Sara Busacca
Annabel J. Sharkey
David Waller
Michael T. Sheaff
Cathy Richards
Peter Wells-Jordan
Aarti Gaba
Charlotte Poile
Essa Y. Baitei
Aleksandra Bzura
Joanna Dzialo
Maymun Jama
John Le Quesne
Amrita Bajaj
Luke Martison
Jacqui A. Shaw
Catrin Pritchard
Tamihiro Kamata
Nathaniel Kuse
Lee Brannan
Pan De Philip Zhang
Hongji Yang
Gareth Griffiths
Gareth Wilson
Charles Swanton
Frank Dudbridge
Edward J. Hollox
Dean A. Fennell
author_sort Min Zhang
title Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
title_short Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
title_full Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
title_fullStr Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
title_full_unstemmed Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
title_sort clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/341b50055bdd45939a6f7909af185de3
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