Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

Influenza virus hemagglutinin (HA) stem between group 1 and 2 viruses has different glycosylation patterns, likely hampering cross-group protection. Here, Boyoglu-Barnum et al. show that introducing a group 2 glycan into a group 1 stem nanoparticle vaccine broadens antibody responses in mice to cros...

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Autores principales:	Seyhan Boyoglu-Barnum, Geoffrey B. Hutchinson, Jeffrey C. Boyington, Syed M. Moin, Rebecca A. Gillespie, Yaroslav Tsybovsky, Tyler Stephens, John R. Vaile, Julia Lederhofer, Kizzmekia S. Corbett, Brian E. Fisher, Hadi M. Yassine, Sarah F. Andrews, Michelle C. Crank, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/341c5ca3cd954a0f92613862f3db746e
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spelling	oai:doaj.org-article:341c5ca3cd954a0f92613862f3db746e2021-12-02T14:41:04ZGlycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses10.1038/s41467-020-14579-42041-1723https://doaj.org/article/341c5ca3cd954a0f92613862f3db746e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14579-4https://doaj.org/toc/2041-1723Influenza virus hemagglutinin (HA) stem between group 1 and 2 viruses has different glycosylation patterns, likely hampering cross-group protection. Here, Boyoglu-Barnum et al. show that introducing a group 2 glycan into a group 1 stem nanoparticle vaccine broadens antibody responses in mice to cross-react with group 2 HAs.Seyhan Boyoglu-BarnumGeoffrey B. HutchinsonJeffrey C. BoyingtonSyed M. MoinRebecca A. GillespieYaroslav TsybovskyTyler StephensJohn R. VaileJulia LederhoferKizzmekia S. CorbettBrian E. FisherHadi M. YassineSarah F. AndrewsMichelle C. CrankAdrian B. McDermottJohn R. MascolaBarney S. GrahamMasaru KanekiyoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seyhan Boyoglu-Barnum Geoffrey B. Hutchinson Jeffrey C. Boyington Syed M. Moin Rebecca A. Gillespie Yaroslav Tsybovsky Tyler Stephens John R. Vaile Julia Lederhofer Kizzmekia S. Corbett Brian E. Fisher Hadi M. Yassine Sarah F. Andrews Michelle C. Crank Adrian B. McDermott John R. Mascola Barney S. Graham Masaru Kanekiyo Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
description	Influenza virus hemagglutinin (HA) stem between group 1 and 2 viruses has different glycosylation patterns, likely hampering cross-group protection. Here, Boyoglu-Barnum et al. show that introducing a group 2 glycan into a group 1 stem nanoparticle vaccine broadens antibody responses in mice to cross-react with group 2 HAs.
format	article
author	Seyhan Boyoglu-Barnum Geoffrey B. Hutchinson Jeffrey C. Boyington Syed M. Moin Rebecca A. Gillespie Yaroslav Tsybovsky Tyler Stephens John R. Vaile Julia Lederhofer Kizzmekia S. Corbett Brian E. Fisher Hadi M. Yassine Sarah F. Andrews Michelle C. Crank Adrian B. McDermott John R. Mascola Barney S. Graham Masaru Kanekiyo
author_facet	Seyhan Boyoglu-Barnum Geoffrey B. Hutchinson Jeffrey C. Boyington Syed M. Moin Rebecca A. Gillespie Yaroslav Tsybovsky Tyler Stephens John R. Vaile Julia Lederhofer Kizzmekia S. Corbett Brian E. Fisher Hadi M. Yassine Sarah F. Andrews Michelle C. Crank Adrian B. McDermott John R. Mascola Barney S. Graham Masaru Kanekiyo
author_sort	Seyhan Boyoglu-Barnum
title	Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
title_short	Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
title_full	Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
title_fullStr	Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
title_full_unstemmed	Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
title_sort	glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/341c5ca3cd954a0f92613862f3db746e
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Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

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