The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern

With the continuation of the pandemic, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have appeared around the world. Owing to a possible risk of increasing the transmissibility of the virus, severity of the infected individuals, and the ability to escape the antibody pro...

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Autores principales:	Lixin Lin, Ying Liu, Xiujuan Tang, Daihai He
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 variants of concerns disease severity mortality epidemic potential COVID-19 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/341cc68124cb487b9228fa05ede061e1
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spelling	oai:doaj.org-article:341cc68124cb487b9228fa05ede061e12021-12-01T16:42:27ZThe Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern2296-256510.3389/fpubh.2021.775224https://doaj.org/article/341cc68124cb487b9228fa05ede061e12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.775224/fullhttps://doaj.org/toc/2296-2565With the continuation of the pandemic, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have appeared around the world. Owing to a possible risk of increasing the transmissibility of the virus, severity of the infected individuals, and the ability to escape the antibody produced by the vaccines, the four SARS-CoV-2 variants of Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) have attracted the most widespread attention. At present, there is a unified conclusion that these four variants have increased the transmissibility of SARS-CoV-2, but the severity of the disease caused by them has not yet been determined. Studies from June 1, 2020 to October 15, 2021 were considered, and a meta-analysis was carried out to process the data. Alpha, Beta, Gamma, and Delta variants are all more serious than the wild-type virus in terms of hospitalization, ICU admission, and mortality, and the Beta and Delta variants have a higher risk than the Alpha and Gamma variants. Notably, the random effects of Beta variant to the wild-type virus with respect to hospitalization rate, severe illness rate, and mortality rate are 2.16 (95% CI: 1.19–3.14), 2.23 (95% CI: 1.31–3.15), and 1.50 (95% CI: 1.26–1.74), respectively, and the random effects of Delta variant to the wild-type virus are 2.08 (95% CI: 1.77–2.39), 3.35 (95% CI: 2.5–4.2), and 2.33 (95% CI: 1.45–3.21), respectively. Although, the emergence of vaccines may reduce the threat posed by SARS-CoV-2 variants, these are still very important, especially the Beta and Delta variants.Lixin LinYing LiuXiujuan TangDaihai HeFrontiers Media S.A.articleSARS-CoV-2variants of concernsdisease severitymortalityepidemic potentialCOVID-19Public aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 variants of concerns disease severity mortality epidemic potential COVID-19 Public aspects of medicine RA1-1270
spellingShingle	SARS-CoV-2 variants of concerns disease severity mortality epidemic potential COVID-19 Public aspects of medicine RA1-1270 Lixin Lin Ying Liu Xiujuan Tang Daihai He The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern
description	With the continuation of the pandemic, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have appeared around the world. Owing to a possible risk of increasing the transmissibility of the virus, severity of the infected individuals, and the ability to escape the antibody produced by the vaccines, the four SARS-CoV-2 variants of Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) have attracted the most widespread attention. At present, there is a unified conclusion that these four variants have increased the transmissibility of SARS-CoV-2, but the severity of the disease caused by them has not yet been determined. Studies from June 1, 2020 to October 15, 2021 were considered, and a meta-analysis was carried out to process the data. Alpha, Beta, Gamma, and Delta variants are all more serious than the wild-type virus in terms of hospitalization, ICU admission, and mortality, and the Beta and Delta variants have a higher risk than the Alpha and Gamma variants. Notably, the random effects of Beta variant to the wild-type virus with respect to hospitalization rate, severe illness rate, and mortality rate are 2.16 (95% CI: 1.19–3.14), 2.23 (95% CI: 1.31–3.15), and 1.50 (95% CI: 1.26–1.74), respectively, and the random effects of Delta variant to the wild-type virus are 2.08 (95% CI: 1.77–2.39), 3.35 (95% CI: 2.5–4.2), and 2.33 (95% CI: 1.45–3.21), respectively. Although, the emergence of vaccines may reduce the threat posed by SARS-CoV-2 variants, these are still very important, especially the Beta and Delta variants.
format	article
author	Lixin Lin Ying Liu Xiujuan Tang Daihai He
author_facet	Lixin Lin Ying Liu Xiujuan Tang Daihai He
author_sort	Lixin Lin
title	The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern
title_short	The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern
title_full	The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern
title_fullStr	The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern
title_full_unstemmed	The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern
title_sort	disease severity and clinical outcomes of the sars-cov-2 variants of concern
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/341cc68124cb487b9228fa05ede061e1
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The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern

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