Saccadic suppression in schizophrenia

Abstract About 40% of schizophrenia patients report discrete visual disturbances which could occur if saccadic suppression, the decrease of visual sensitivity around saccade onset, is impaired. Two mechanisms contribute to saccadic suppression: efference copy processing and backwards masking. Both a...

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Autores principales:	Rebekka Lencer, Inga Meyhöfer, Janina Triebsch, Karen Rolfes, Markus Lappe, Tamara Watson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/341d86a73ff84bad87c9a60e773a7b8c
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spelling	oai:doaj.org-article:341d86a73ff84bad87c9a60e773a7b8c2021-12-02T18:02:54ZSaccadic suppression in schizophrenia10.1038/s41598-021-92531-22045-2322https://doaj.org/article/341d86a73ff84bad87c9a60e773a7b8c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92531-2https://doaj.org/toc/2045-2322Abstract About 40% of schizophrenia patients report discrete visual disturbances which could occur if saccadic suppression, the decrease of visual sensitivity around saccade onset, is impaired. Two mechanisms contribute to saccadic suppression: efference copy processing and backwards masking. Both are reportedly altered in schizophrenia. However, saccadic suppression has not been investigated in schizophrenia. 17 schizophrenia patients and 18 healthy controls performed a saccadic suppression task using a Gabor stimulus with individually adjusted contrast, which was presented within an interval 300 ms around saccade onset. Visual disturbance scores were higher in patients than controls, but saccadic suppression strength and time course were similar in both groups with lower saccadic suppression rates being similarly related to smaller saccade amplitudes. Saccade amplitudes in the saccadic suppression task were reduced in patients, in contrast to unaltered amplitudes during a saccade control task. Notably, smaller saccade amplitudes were related to higher visual disturbances scores in patients. Saccadic suppression performance was unrelated to symptom expression and antipsychotic medication. Unaltered saccadic suppression in patients suggests sufficiently intact efference copy processing and backward masking as required for this task. Instead, visual disturbances in patients may be related to restricted saccadic amplitudes arising from cognitive load while completing a task.Rebekka LencerInga MeyhöferJanina TriebschKaren RolfesMarkus LappeTamara WatsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebekka Lencer Inga Meyhöfer Janina Triebsch Karen Rolfes Markus Lappe Tamara Watson Saccadic suppression in schizophrenia
description	Abstract About 40% of schizophrenia patients report discrete visual disturbances which could occur if saccadic suppression, the decrease of visual sensitivity around saccade onset, is impaired. Two mechanisms contribute to saccadic suppression: efference copy processing and backwards masking. Both are reportedly altered in schizophrenia. However, saccadic suppression has not been investigated in schizophrenia. 17 schizophrenia patients and 18 healthy controls performed a saccadic suppression task using a Gabor stimulus with individually adjusted contrast, which was presented within an interval 300 ms around saccade onset. Visual disturbance scores were higher in patients than controls, but saccadic suppression strength and time course were similar in both groups with lower saccadic suppression rates being similarly related to smaller saccade amplitudes. Saccade amplitudes in the saccadic suppression task were reduced in patients, in contrast to unaltered amplitudes during a saccade control task. Notably, smaller saccade amplitudes were related to higher visual disturbances scores in patients. Saccadic suppression performance was unrelated to symptom expression and antipsychotic medication. Unaltered saccadic suppression in patients suggests sufficiently intact efference copy processing and backward masking as required for this task. Instead, visual disturbances in patients may be related to restricted saccadic amplitudes arising from cognitive load while completing a task.
format	article
author	Rebekka Lencer Inga Meyhöfer Janina Triebsch Karen Rolfes Markus Lappe Tamara Watson
author_facet	Rebekka Lencer Inga Meyhöfer Janina Triebsch Karen Rolfes Markus Lappe Tamara Watson
author_sort	Rebekka Lencer
title	Saccadic suppression in schizophrenia
title_short	Saccadic suppression in schizophrenia
title_full	Saccadic suppression in schizophrenia
title_fullStr	Saccadic suppression in schizophrenia
title_full_unstemmed	Saccadic suppression in schizophrenia
title_sort	saccadic suppression in schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/341d86a73ff84bad87c9a60e773a7b8c
work_keys_str_mv	AT rebekkalencer saccadicsuppressioninschizophrenia AT ingameyhofer saccadicsuppressioninschizophrenia AT janinatriebsch saccadicsuppressioninschizophrenia AT karenrolfes saccadicsuppressioninschizophrenia AT markuslappe saccadicsuppressioninschizophrenia AT tamarawatson saccadicsuppressioninschizophrenia
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Saccadic suppression in schizophrenia

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