The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region

Abstract Adverse reactions may still occur in some patients after receiving haematopoietic stem cell transplantation (HSCT), even when choosing a human leukocyte antigen (HLA)-matched donor. The adverse reactions of transplantation include disease relapse, graft-versus-host disease (GVHD), mortality...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ding-Ping Chen, Ying-Hao Wen, Po-Nan Wang, Ai-Ling Hour, Wei-Tzu Lin, Fang-Ping Hsu, Wei-Ting Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/341fcb8c5edd4cc39e5461f3edffd8a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:341fcb8c5edd4cc39e5461f3edffd8a2
record_format	dspace
spelling	oai:doaj.org-article:341fcb8c5edd4cc39e5461f3edffd8a22021-12-02T14:01:23ZThe adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region10.1038/s41598-020-79369-w2045-2322https://doaj.org/article/341fcb8c5edd4cc39e5461f3edffd8a22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79369-whttps://doaj.org/toc/2045-2322Abstract Adverse reactions may still occur in some patients after receiving haematopoietic stem cell transplantation (HSCT), even when choosing a human leukocyte antigen (HLA)-matched donor. The adverse reactions of transplantation include disease relapse, graft-versus-host disease (GVHD), mortality and CMV infection. However, only the relapse was discussed in our previous study. Therefore, in this study, we investigated the correlation between the gene polymorphisms within the HLA region and the adverse reactions of post-HSCT in patients with acute leukaemia (n = 176), where 72 patients were diagnosed with acute lymphocytic leukaemia (ALL) and 104 were acute myeloid leukaemia (AML). The candidate single nucleotide polymorphisms were divided into three models: donor, recipient, and donor-recipient pairs and the data of ALL and AML were analysed individually. Based on the results, we found 16 SNPs associated with the survival rates, the risk of CMV infection, or the grade of GVHD in either donor, recipient, or donor-recipient matching models. In the ALL group, the rs209132 of TRIM27 in the donor group was related to CMV infection (p = 0.021), the rs213210 of RING1 in the recipient group was associated with serious GVHD (p = 0.003), and the rs2227956 of HSPA1L in the recipient group correlated with CMV infection (p = 0.001). In the AML group, the rs3130048 of BAG6 in the donor-recipient pairs group was associated with serious GVHD (p = 0.048). Moreover, these SNPs were further associated with the duration time of survival after transplantation. These results could be applied to select the best donor in HSCT.Ding-Ping ChenYing-Hao WenPo-Nan WangAi-Ling HourWei-Tzu LinFang-Ping HsuWei-Ting WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ding-Ping Chen Ying-Hao Wen Po-Nan Wang Ai-Ling Hour Wei-Tzu Lin Fang-Ping Hsu Wei-Ting Wang The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region
description	Abstract Adverse reactions may still occur in some patients after receiving haematopoietic stem cell transplantation (HSCT), even when choosing a human leukocyte antigen (HLA)-matched donor. The adverse reactions of transplantation include disease relapse, graft-versus-host disease (GVHD), mortality and CMV infection. However, only the relapse was discussed in our previous study. Therefore, in this study, we investigated the correlation between the gene polymorphisms within the HLA region and the adverse reactions of post-HSCT in patients with acute leukaemia (n = 176), where 72 patients were diagnosed with acute lymphocytic leukaemia (ALL) and 104 were acute myeloid leukaemia (AML). The candidate single nucleotide polymorphisms were divided into three models: donor, recipient, and donor-recipient pairs and the data of ALL and AML were analysed individually. Based on the results, we found 16 SNPs associated with the survival rates, the risk of CMV infection, or the grade of GVHD in either donor, recipient, or donor-recipient matching models. In the ALL group, the rs209132 of TRIM27 in the donor group was related to CMV infection (p = 0.021), the rs213210 of RING1 in the recipient group was associated with serious GVHD (p = 0.003), and the rs2227956 of HSPA1L in the recipient group correlated with CMV infection (p = 0.001). In the AML group, the rs3130048 of BAG6 in the donor-recipient pairs group was associated with serious GVHD (p = 0.048). Moreover, these SNPs were further associated with the duration time of survival after transplantation. These results could be applied to select the best donor in HSCT.
format	article
author	Ding-Ping Chen Ying-Hao Wen Po-Nan Wang Ai-Ling Hour Wei-Tzu Lin Fang-Ping Hsu Wei-Ting Wang
author_facet	Ding-Ping Chen Ying-Hao Wen Po-Nan Wang Ai-Ling Hour Wei-Tzu Lin Fang-Ping Hsu Wei-Ting Wang
author_sort	Ding-Ping Chen
title	The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region
title_short	The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region
title_full	The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region
title_fullStr	The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region
title_full_unstemmed	The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region
title_sort	adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/341fcb8c5edd4cc39e5461f3edffd8a2
work_keys_str_mv	AT dingpingchen theadverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT yinghaowen theadverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT ponanwang theadverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT ailinghour theadverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT weitzulin theadverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT fangpinghsu theadverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT weitingwang theadverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT dingpingchen adverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT yinghaowen adverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT ponanwang adverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT ailinghour adverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT weitzulin adverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT fangpinghsu adverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion AT weitingwang adverseeventsofhaematopoieticstemcelltransplantationareassociatedwithgenepolymorphismwithinhumanleukocyteantigenregion
_version_	1718392132057694208

The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region

Ejemplares similares