Rate of entropy model for irreversible processes in living systems

Abstract In living systems, it is crucial to study the exchange of entropy that plays a fundamental role in the understanding of irreversible chemical reactions. However, there are not yet works able to describe in a systematic way the rate of entropy production associated to irreversible processes....

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Autores principales:	R. Zivieri, N. Pacini, G. Finocchio, M. Carpentieri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34233ffc70a74294bf85bcc3b7d40013
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spelling	oai:doaj.org-article:34233ffc70a74294bf85bcc3b7d400132021-12-02T11:53:08ZRate of entropy model for irreversible processes in living systems10.1038/s41598-017-09530-52045-2322https://doaj.org/article/34233ffc70a74294bf85bcc3b7d400132017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09530-5https://doaj.org/toc/2045-2322Abstract In living systems, it is crucial to study the exchange of entropy that plays a fundamental role in the understanding of irreversible chemical reactions. However, there are not yet works able to describe in a systematic way the rate of entropy production associated to irreversible processes. Hence, here we develop a theoretical model to compute the rate of entropy in the minimum living system. In particular, we apply the model to the most interesting and relevant case of metabolic network, the glucose catabolism in normal and cancer cells. We show, (i) the rate of internal entropy is mainly due to irreversible chemical reactions, and (ii) the rate of external entropy is mostly correlated to the heat flow towards the intercellular environment. The future applications of our model could be of fundamental importance for a more complete understanding of self-renewal and physiopatologic processes and could potentially be a support for cancer detection.R. ZivieriN. PaciniG. FinocchioM. CarpentieriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q R. Zivieri N. Pacini G. Finocchio M. Carpentieri Rate of entropy model for irreversible processes in living systems
description	Abstract In living systems, it is crucial to study the exchange of entropy that plays a fundamental role in the understanding of irreversible chemical reactions. However, there are not yet works able to describe in a systematic way the rate of entropy production associated to irreversible processes. Hence, here we develop a theoretical model to compute the rate of entropy in the minimum living system. In particular, we apply the model to the most interesting and relevant case of metabolic network, the glucose catabolism in normal and cancer cells. We show, (i) the rate of internal entropy is mainly due to irreversible chemical reactions, and (ii) the rate of external entropy is mostly correlated to the heat flow towards the intercellular environment. The future applications of our model could be of fundamental importance for a more complete understanding of self-renewal and physiopatologic processes and could potentially be a support for cancer detection.
format	article
author	R. Zivieri N. Pacini G. Finocchio M. Carpentieri
author_facet	R. Zivieri N. Pacini G. Finocchio M. Carpentieri
author_sort	R. Zivieri
title	Rate of entropy model for irreversible processes in living systems
title_short	Rate of entropy model for irreversible processes in living systems
title_full	Rate of entropy model for irreversible processes in living systems
title_fullStr	Rate of entropy model for irreversible processes in living systems
title_full_unstemmed	Rate of entropy model for irreversible processes in living systems
title_sort	rate of entropy model for irreversible processes in living systems
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/34233ffc70a74294bf85bcc3b7d40013
work_keys_str_mv	AT rzivieri rateofentropymodelforirreversibleprocessesinlivingsystems AT npacini rateofentropymodelforirreversibleprocessesinlivingsystems AT gfinocchio rateofentropymodelforirreversibleprocessesinlivingsystems AT mcarpentieri rateofentropymodelforirreversibleprocessesinlivingsystems
_version_	1718394859031625728

Rate of entropy model for irreversible processes in living systems

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