Action potential broadening in a presynaptic channelopathy

Episodic ataxia type 1 is caused by mutations in the potassium channel Kv1.1, which is found in cerebellar basket cells. Here, the authors use electrophysiology techniques to characterize these mutant channels, and observe that the changes result in decreased spontaneous Purkinje cell firing with no...

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Autores principales:	Rahima Begum, Yamina Bakiri, Kirill E. Volynski, Dimitri M. Kullmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34260921036645c1afdf57d613180339
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spelling	oai:doaj.org-article:34260921036645c1afdf57d6131803392021-12-02T17:32:23ZAction potential broadening in a presynaptic channelopathy10.1038/ncomms121022041-1723https://doaj.org/article/34260921036645c1afdf57d6131803392016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12102https://doaj.org/toc/2041-1723Episodic ataxia type 1 is caused by mutations in the potassium channel Kv1.1, which is found in cerebellar basket cells. Here, the authors use electrophysiology techniques to characterize these mutant channels, and observe that the changes result in decreased spontaneous Purkinje cell firing with no evidence for developmental compensation.Rahima BegumYamina BakiriKirill E. VolynskiDimitri M. KullmannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rahima Begum Yamina Bakiri Kirill E. Volynski Dimitri M. Kullmann Action potential broadening in a presynaptic channelopathy
description	Episodic ataxia type 1 is caused by mutations in the potassium channel Kv1.1, which is found in cerebellar basket cells. Here, the authors use electrophysiology techniques to characterize these mutant channels, and observe that the changes result in decreased spontaneous Purkinje cell firing with no evidence for developmental compensation.
format	article
author	Rahima Begum Yamina Bakiri Kirill E. Volynski Dimitri M. Kullmann
author_facet	Rahima Begum Yamina Bakiri Kirill E. Volynski Dimitri M. Kullmann
author_sort	Rahima Begum
title	Action potential broadening in a presynaptic channelopathy
title_short	Action potential broadening in a presynaptic channelopathy
title_full	Action potential broadening in a presynaptic channelopathy
title_fullStr	Action potential broadening in a presynaptic channelopathy
title_full_unstemmed	Action potential broadening in a presynaptic channelopathy
title_sort	action potential broadening in a presynaptic channelopathy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/34260921036645c1afdf57d613180339
work_keys_str_mv	AT rahimabegum actionpotentialbroadeninginapresynapticchannelopathy AT yaminabakiri actionpotentialbroadeninginapresynapticchannelopathy AT kirillevolynski actionpotentialbroadeninginapresynapticchannelopathy AT dimitrimkullmann actionpotentialbroadeninginapresynapticchannelopathy
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Action potential broadening in a presynaptic channelopathy

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