Immunological predictors of type 1 diabetes mellitus (literature review)

Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by insulin deficiency due β-cell destruction and following hyperglycaemia. Specific markers of T1DM are pancreatic islet-targeting autoantibodies that are found months to years before symptom onset, and can be...

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Autores principales:	K. G. Korneva, L. G. Strongin, V. E. Zagainov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	type 1 diabetes mellitus autoantibodies systematic review Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/342669195ed3417088a11d57df81a12e
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spelling	oai:doaj.org-article:342669195ed3417088a11d57df81a12e2021-11-14T09:00:23ZImmunological predictors of type 1 diabetes mellitus (literature review)2072-03512072-037810.14341/DM12308https://doaj.org/article/342669195ed3417088a11d57df81a12e2021-07-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12308https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by insulin deficiency due β-cell destruction and following hyperglycaemia. Specific markers of T1DM are pancreatic islet-targeting autoantibodies that are found months to years before symptom onset, and can be used to identify individuals who are at risk of developing T1DM.Aim: The study is aimed at the review of current knowledge of diabetes-related autoantibodies as biomarkers of T1DM.Materials and methods: Foreign and national clinical studies on this topic were included. PubMed, Medline and eLibrary were searched.Results: Modern ideas about known diabetes-specific autoantibodies as markers of autoimmune inflammation of β-cells of the pancreas were discussed. The analysis of their independent diagnostic value in predicting the occurrence of T1DM were carried out.Conclusion: There is no unified concept in the literature on this issue. Current data on autoantibodies in T1DM show a significant individual variability in the timing, dynamic changes and autoantibody composition in T1DM progression.K. G. KornevaL. G. StronginV. E. ZagainovEndocrinology Research Centrearticletype 1 diabetes mellitusautoantibodiessystematic reviewNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 2, Pp 167-174 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus autoantibodies systematic review Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus autoantibodies systematic review Nutritional diseases. Deficiency diseases RC620-627 K. G. Korneva L. G. Strongin V. E. Zagainov Immunological predictors of type 1 diabetes mellitus (literature review)
description	Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by insulin deficiency due β-cell destruction and following hyperglycaemia. Specific markers of T1DM are pancreatic islet-targeting autoantibodies that are found months to years before symptom onset, and can be used to identify individuals who are at risk of developing T1DM.Aim: The study is aimed at the review of current knowledge of diabetes-related autoantibodies as biomarkers of T1DM.Materials and methods: Foreign and national clinical studies on this topic were included. PubMed, Medline and eLibrary were searched.Results: Modern ideas about known diabetes-specific autoantibodies as markers of autoimmune inflammation of β-cells of the pancreas were discussed. The analysis of their independent diagnostic value in predicting the occurrence of T1DM were carried out.Conclusion: There is no unified concept in the literature on this issue. Current data on autoantibodies in T1DM show a significant individual variability in the timing, dynamic changes and autoantibody composition in T1DM progression.
format	article
author	K. G. Korneva L. G. Strongin V. E. Zagainov
author_facet	K. G. Korneva L. G. Strongin V. E. Zagainov
author_sort	K. G. Korneva
title	Immunological predictors of type 1 diabetes mellitus (literature review)
title_short	Immunological predictors of type 1 diabetes mellitus (literature review)
title_full	Immunological predictors of type 1 diabetes mellitus (literature review)
title_fullStr	Immunological predictors of type 1 diabetes mellitus (literature review)
title_full_unstemmed	Immunological predictors of type 1 diabetes mellitus (literature review)
title_sort	immunological predictors of type 1 diabetes mellitus (literature review)
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/342669195ed3417088a11d57df81a12e
work_keys_str_mv	AT kgkorneva immunologicalpredictorsoftype1diabetesmellitusliteraturereview AT lgstrongin immunologicalpredictorsoftype1diabetesmellitusliteraturereview AT vezagainov immunologicalpredictorsoftype1diabetesmellitusliteraturereview
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Immunological predictors of type 1 diabetes mellitus (literature review)

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