CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
Repeat-associated non-AUG (RAN) translation contributes to the pathogenic mechanism of several microsatellite expansion diseases. Here the authors delineate the different steps involved in recruiting the ribosome to initiate G4C2 RAN translation to produce poly-Glycine Alanine, poly-Glycine Proline,...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3426ab0a50b1414493710f574ce831d4 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3426ab0a50b1414493710f574ce831d4 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3426ab0a50b1414493710f574ce831d42021-12-02T17:32:00ZCUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts10.1038/s41467-017-02643-52041-1723https://doaj.org/article/3426ab0a50b1414493710f574ce831d42018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02643-5https://doaj.org/toc/2041-1723Repeat-associated non-AUG (RAN) translation contributes to the pathogenic mechanism of several microsatellite expansion diseases. Here the authors delineate the different steps involved in recruiting the ribosome to initiate G4C2 RAN translation to produce poly-Glycine Alanine, poly-Glycine Proline, and poly-Glycine Arginine repeats.Ricardos TabetLaure SchaefferFernande FreyermuthMelanie JambeauMichael WorkmanChao-Zong LeeChun-Chia LinJie JiangKaren Jansen-WestHussein Abou-HamdanLaurent DésaubryTania GendronLeonard PetrucelliFranck MartinClotilde Lagier-TourenneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ricardos Tabet Laure Schaeffer Fernande Freyermuth Melanie Jambeau Michael Workman Chao-Zong Lee Chun-Chia Lin Jie Jiang Karen Jansen-West Hussein Abou-Hamdan Laurent Désaubry Tania Gendron Leonard Petrucelli Franck Martin Clotilde Lagier-Tourenne CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts |
| description |
Repeat-associated non-AUG (RAN) translation contributes to the pathogenic mechanism of several microsatellite expansion diseases. Here the authors delineate the different steps involved in recruiting the ribosome to initiate G4C2 RAN translation to produce poly-Glycine Alanine, poly-Glycine Proline, and poly-Glycine Arginine repeats. |
| format |
article |
| author |
Ricardos Tabet Laure Schaeffer Fernande Freyermuth Melanie Jambeau Michael Workman Chao-Zong Lee Chun-Chia Lin Jie Jiang Karen Jansen-West Hussein Abou-Hamdan Laurent Désaubry Tania Gendron Leonard Petrucelli Franck Martin Clotilde Lagier-Tourenne |
| author_facet |
Ricardos Tabet Laure Schaeffer Fernande Freyermuth Melanie Jambeau Michael Workman Chao-Zong Lee Chun-Chia Lin Jie Jiang Karen Jansen-West Hussein Abou-Hamdan Laurent Désaubry Tania Gendron Leonard Petrucelli Franck Martin Clotilde Lagier-Tourenne |
| author_sort |
Ricardos Tabet |
| title |
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts |
| title_short |
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts |
| title_full |
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts |
| title_fullStr |
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts |
| title_full_unstemmed |
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts |
| title_sort |
cug initiation and frameshifting enable production of dipeptide repeat proteins from als/ftd c9orf72 transcripts |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/3426ab0a50b1414493710f574ce831d4 |
| work_keys_str_mv |
AT ricardostabet cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT laureschaeffer cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT fernandefreyermuth cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT melaniejambeau cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT michaelworkman cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT chaozonglee cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT chunchialin cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT jiejiang cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT karenjansenwest cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT husseinabouhamdan cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT laurentdesaubry cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT taniagendron cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT leonardpetrucelli cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT franckmartin cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts AT clotildelagiertourenne cuginitiationandframeshiftingenableproductionofdipeptiderepeatproteinsfromalsftdc9orf72transcripts |
| _version_ |
1718380422032785408 |