Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Neuropathic pain hypersensitivity is known to undergo diurnal variations, although the underlying mechanisms are not clear. Using a sciatic nerve-injury mouse model, the authors find such diurnal changes are mediated by glucocorticoid induced enhancement of ATP release from astrocytes via pannexin-1...

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Autores principales:	Satoru Koyanagi, Naoki Kusunose, Marie Taniguchi, Takahiro Akamine, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Kohro, Naoya Matsunaga, Makoto Tsuda, Michael W. Salter, Kazuhide Inoue, Shigehiro Ohdo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3429b7f186f44d12bff9bb7521dc6cb3
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spelling	oai:doaj.org-article:3429b7f186f44d12bff9bb7521dc6cb32021-12-02T15:35:44ZGlucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia10.1038/ncomms131022041-1723https://doaj.org/article/3429b7f186f44d12bff9bb7521dc6cb32016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13102https://doaj.org/toc/2041-1723Neuropathic pain hypersensitivity is known to undergo diurnal variations, although the underlying mechanisms are not clear. Using a sciatic nerve-injury mouse model, the authors find such diurnal changes are mediated by glucocorticoid induced enhancement of ATP release from astrocytes via pannexin-1 hemichannels.Satoru KoyanagiNaoki KusunoseMarie TaniguchiTakahiro AkamineYuki KanadoYui OzonoTakahiro MasudaYuta KohroNaoya MatsunagaMakoto TsudaMichael W. SalterKazuhide InoueShigehiro OhdoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoru Koyanagi Naoki Kusunose Marie Taniguchi Takahiro Akamine Yuki Kanado Yui Ozono Takahiro Masuda Yuta Kohro Naoya Matsunaga Makoto Tsuda Michael W. Salter Kazuhide Inoue Shigehiro Ohdo Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
description	Neuropathic pain hypersensitivity is known to undergo diurnal variations, although the underlying mechanisms are not clear. Using a sciatic nerve-injury mouse model, the authors find such diurnal changes are mediated by glucocorticoid induced enhancement of ATP release from astrocytes via pannexin-1 hemichannels.
format	article
author	Satoru Koyanagi Naoki Kusunose Marie Taniguchi Takahiro Akamine Yuki Kanado Yui Ozono Takahiro Masuda Yuta Kohro Naoya Matsunaga Makoto Tsuda Michael W. Salter Kazuhide Inoue Shigehiro Ohdo
author_facet	Satoru Koyanagi Naoki Kusunose Marie Taniguchi Takahiro Akamine Yuki Kanado Yui Ozono Takahiro Masuda Yuta Kohro Naoya Matsunaga Makoto Tsuda Michael W. Salter Kazuhide Inoue Shigehiro Ohdo
author_sort	Satoru Koyanagi
title	Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
title_short	Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
title_full	Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
title_fullStr	Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
title_full_unstemmed	Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
title_sort	glucocorticoid regulation of atp release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3429b7f186f44d12bff9bb7521dc6cb3
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Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

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