A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.

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Autores principales:	Jlenia Guarnerio, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S. Frenette, Keisuke Ito, Pier Paolo Pandolfi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/342cc2d1a19c42458ab298d79230142d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:342cc2d1a19c42458ab298d79230142d2021-12-02T14:40:30ZA non-cell-autonomous role for Pml in the maintenance of leukemia from the niche10.1038/s41467-017-02427-x2041-1723https://doaj.org/article/342cc2d1a19c42458ab298d79230142d2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02427-xhttps://doaj.org/toc/2041-1723Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.Jlenia GuarnerioLourdes Maria MendezNoboru AsadaArchita Venugopal MenonJacqueline FungKelsey BerryPaul S. FrenetteKeisuke ItoPier Paolo PandolfiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
description	Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.
format	article
author	Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi
author_facet	Jlenia Guarnerio Lourdes Maria Mendez Noboru Asada Archita Venugopal Menon Jacqueline Fung Kelsey Berry Paul S. Frenette Keisuke Ito Pier Paolo Pandolfi
author_sort	Jlenia Guarnerio
title	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_short	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_full	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_fullStr	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_full_unstemmed	A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
title_sort	non-cell-autonomous role for pml in the maintenance of leukemia from the niche
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/342cc2d1a19c42458ab298d79230142d
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A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

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