Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules

The mechanisms underlying synaptic heterogeneity of neurotransmission at mature calyx synapses remain unclear. Here, authors identify two morphological modules that have distinct topology of calcium channel clusters and spatial coupling distance to synaptic vesicles, which may account for different...

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Autores principales:	Adam Fekete, Yukihiro Nakamura, Yi-Mei Yang, Stefan Herlitze, Melanie D. Mark, David A. DiGregorio, Lu-Yang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/342e2fb457a34f4ab2812f5d3c07851d
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spelling	oai:doaj.org-article:342e2fb457a34f4ab2812f5d3c07851d2021-12-02T17:32:55ZUnderpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules10.1038/s41467-019-08452-22041-1723https://doaj.org/article/342e2fb457a34f4ab2812f5d3c07851d2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08452-2https://doaj.org/toc/2041-1723The mechanisms underlying synaptic heterogeneity of neurotransmission at mature calyx synapses remain unclear. Here, authors identify two morphological modules that have distinct topology of calcium channel clusters and spatial coupling distance to synaptic vesicles, which may account for different release probability and short-term plasticity in calyces with differing morphology.Adam FeketeYukihiro NakamuraYi-Mei YangStefan HerlitzeMelanie D. MarkDavid A. DiGregorioLu-Yang WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam Fekete Yukihiro Nakamura Yi-Mei Yang Stefan Herlitze Melanie D. Mark David A. DiGregorio Lu-Yang Wang Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
description	The mechanisms underlying synaptic heterogeneity of neurotransmission at mature calyx synapses remain unclear. Here, authors identify two morphological modules that have distinct topology of calcium channel clusters and spatial coupling distance to synaptic vesicles, which may account for different release probability and short-term plasticity in calyces with differing morphology.
format	article
author	Adam Fekete Yukihiro Nakamura Yi-Mei Yang Stefan Herlitze Melanie D. Mark David A. DiGregorio Lu-Yang Wang
author_facet	Adam Fekete Yukihiro Nakamura Yi-Mei Yang Stefan Herlitze Melanie D. Mark David A. DiGregorio Lu-Yang Wang
author_sort	Adam Fekete
title	Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
title_short	Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
title_full	Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
title_fullStr	Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
title_full_unstemmed	Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
title_sort	underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/342e2fb457a34f4ab2812f5d3c07851d
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Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules

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