The dental plaque microbiome in health and disease.

Dental decay is one of the most prevalent chronic diseases worldwide. A variety of factors, including microbial, genetic, immunological, behavioral and environmental, interact to contribute to dental caries onset and development. Previous studies focused on the microbial basis for dental caries have...

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Autores principales:	Scott N Peterson, Erik Snesrud, Jia Liu, Ana C Ong, Mogens Kilian, Nicholas J Schork, Walter Bretz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3430cddf78dd4405b3e8e1ff7d55dd43
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spelling	oai:doaj.org-article:3430cddf78dd4405b3e8e1ff7d55dd432021-11-18T07:54:09ZThe dental plaque microbiome in health and disease.1932-620310.1371/journal.pone.0058487https://doaj.org/article/3430cddf78dd4405b3e8e1ff7d55dd432013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23520516/?tool=EBIhttps://doaj.org/toc/1932-6203Dental decay is one of the most prevalent chronic diseases worldwide. A variety of factors, including microbial, genetic, immunological, behavioral and environmental, interact to contribute to dental caries onset and development. Previous studies focused on the microbial basis for dental caries have identified species associated with both dental health and disease. The purpose of the current study was to improve our knowledge of the microbial species involved in dental caries and health by performing a comprehensive 16S rDNA profiling of the dental plaque microbiome of both caries-free and caries-active subjects. Analysis of over 50,000 nearly full-length 16S rDNA clones allowed the identification of 1,372 operational taxonomic units (OTUs) in the dental plaque microbiome. Approximately half of the OTUs were common to both caries-free and caries-active microbiomes and present at similar abundance. The majority of differences in OTU's reflected very low abundance phylotypes. This survey allowed us to define the population structure of the dental plaque microbiome and to identify the microbial signatures associated with dental health and disease. The deep profiling of dental plaque allowed the identification of 87 phylotypes that are over-represented in either caries-free or caries-active subjects. Among these signatures, those associated with dental health outnumbered those associated with dental caries by nearly two-fold. A comparison of this data to other published studies indicate significant heterogeneity in study outcomes and suggest that novel approaches may be required to further define the signatures of dental caries onset and progression.Scott N PetersonErik SnesrudJia LiuAna C OngMogens KilianNicholas J SchorkWalter BretzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58487 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Scott N Peterson Erik Snesrud Jia Liu Ana C Ong Mogens Kilian Nicholas J Schork Walter Bretz The dental plaque microbiome in health and disease.
description	Dental decay is one of the most prevalent chronic diseases worldwide. A variety of factors, including microbial, genetic, immunological, behavioral and environmental, interact to contribute to dental caries onset and development. Previous studies focused on the microbial basis for dental caries have identified species associated with both dental health and disease. The purpose of the current study was to improve our knowledge of the microbial species involved in dental caries and health by performing a comprehensive 16S rDNA profiling of the dental plaque microbiome of both caries-free and caries-active subjects. Analysis of over 50,000 nearly full-length 16S rDNA clones allowed the identification of 1,372 operational taxonomic units (OTUs) in the dental plaque microbiome. Approximately half of the OTUs were common to both caries-free and caries-active microbiomes and present at similar abundance. The majority of differences in OTU's reflected very low abundance phylotypes. This survey allowed us to define the population structure of the dental plaque microbiome and to identify the microbial signatures associated with dental health and disease. The deep profiling of dental plaque allowed the identification of 87 phylotypes that are over-represented in either caries-free or caries-active subjects. Among these signatures, those associated with dental health outnumbered those associated with dental caries by nearly two-fold. A comparison of this data to other published studies indicate significant heterogeneity in study outcomes and suggest that novel approaches may be required to further define the signatures of dental caries onset and progression.
format	article
author	Scott N Peterson Erik Snesrud Jia Liu Ana C Ong Mogens Kilian Nicholas J Schork Walter Bretz
author_facet	Scott N Peterson Erik Snesrud Jia Liu Ana C Ong Mogens Kilian Nicholas J Schork Walter Bretz
author_sort	Scott N Peterson
title	The dental plaque microbiome in health and disease.
title_short	The dental plaque microbiome in health and disease.
title_full	The dental plaque microbiome in health and disease.
title_fullStr	The dental plaque microbiome in health and disease.
title_full_unstemmed	The dental plaque microbiome in health and disease.
title_sort	dental plaque microbiome in health and disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/3430cddf78dd4405b3e8e1ff7d55dd43
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The dental plaque microbiome in health and disease.

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