Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing

Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing

The pathogenesis of oesophageal squamous cell carcinoma is a multi-step process but the genetic determinants behind this progression are unknown. Here the authors use multi-region exome sequencing to comprehensively investigate the genetic evolution of precursor dysplastic lesions and untransformed...

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Autores principales: Xi-Xi Chen, Qian Zhong, Yang Liu, Shu-Mei Yan, Zhang-Hua Chen, Shan-Zhao Jin, Tian-Liang Xia, Ruo-Yan Li, Ai-Jun Zhou, Zhe Su, Yu-Hua Huang, Qi-Tao Huang, Li-Yun Huang, Xing Zhang, Yan-Na Zhao, Jin-Ping Yun, Qiu-Liang Wu, Dong-Xin Lin, Fan Bai, Mu-Sheng Zeng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3432ab8a3ea44a19a8be00b2d3f5e2fc
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spelling oai:doaj.org-article:3432ab8a3ea44a19a8be00b2d3f5e2fc2021-12-02T15:38:37ZGenomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing10.1038/s41467-017-00650-02041-1723https://doaj.org/article/3432ab8a3ea44a19a8be00b2d3f5e2fc2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00650-0https://doaj.org/toc/2041-1723The pathogenesis of oesophageal squamous cell carcinoma is a multi-step process but the genetic determinants behind this progression are unknown. Here the authors use multi-region exome sequencing to comprehensively investigate the genetic evolution of precursor dysplastic lesions and untransformed oesophagus.Xi-Xi ChenQian ZhongYang LiuShu-Mei YanZhang-Hua ChenShan-Zhao JinTian-Liang XiaRuo-Yan LiAi-Jun ZhouZhe SuYu-Hua HuangQi-Tao HuangLi-Yun HuangXing ZhangYan-Na ZhaoJin-Ping YunQiu-Liang WuDong-Xin LinFan BaiMu-Sheng ZengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xi-Xi Chen
Qian Zhong
Yang Liu
Shu-Mei Yan
Zhang-Hua Chen
Shan-Zhao Jin
Tian-Liang Xia
Ruo-Yan Li
Ai-Jun Zhou
Zhe Su
Yu-Hua Huang
Qi-Tao Huang
Li-Yun Huang
Xing Zhang
Yan-Na Zhao
Jin-Ping Yun
Qiu-Liang Wu
Dong-Xin Lin
Fan Bai
Mu-Sheng Zeng
Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
description The pathogenesis of oesophageal squamous cell carcinoma is a multi-step process but the genetic determinants behind this progression are unknown. Here the authors use multi-region exome sequencing to comprehensively investigate the genetic evolution of precursor dysplastic lesions and untransformed oesophagus.
format article
author Xi-Xi Chen
Qian Zhong
Yang Liu
Shu-Mei Yan
Zhang-Hua Chen
Shan-Zhao Jin
Tian-Liang Xia
Ruo-Yan Li
Ai-Jun Zhou
Zhe Su
Yu-Hua Huang
Qi-Tao Huang
Li-Yun Huang
Xing Zhang
Yan-Na Zhao
Jin-Ping Yun
Qiu-Liang Wu
Dong-Xin Lin
Fan Bai
Mu-Sheng Zeng
author_facet Xi-Xi Chen
Qian Zhong
Yang Liu
Shu-Mei Yan
Zhang-Hua Chen
Shan-Zhao Jin
Tian-Liang Xia
Ruo-Yan Li
Ai-Jun Zhou
Zhe Su
Yu-Hua Huang
Qi-Tao Huang
Li-Yun Huang
Xing Zhang
Yan-Na Zhao
Jin-Ping Yun
Qiu-Liang Wu
Dong-Xin Lin
Fan Bai
Mu-Sheng Zeng
author_sort Xi-Xi Chen
title Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
title_short Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
title_full Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
title_fullStr Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
title_full_unstemmed Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
title_sort genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3432ab8a3ea44a19a8be00b2d3f5e2fc
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