A pilot study to assess the healing of meniscal tears in young adult goats

Abstract Meniscal tears are a common orthopedic injury, yet their healing is difficult to assess post-operatively. This impedes clinical decisions as the healing status of the meniscus cannot be accurately determined non-invasively. Thus, the objectives of this study were to explore the utility of a...

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Autores principales:	William Fedje-Johnston, Casey P. Johnson, Ferenc Tóth, Cathy S. Carlson, Arin M. Ellingson, Melissa Albersheim, Jack Lewis, Joan Bechtold, Jutta Ellermann, Aaron Rendahl, Marc Tompkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/343591bb075046179bda7313a9e4cf52
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spelling	oai:doaj.org-article:343591bb075046179bda7313a9e4cf522021-12-02T16:14:46ZA pilot study to assess the healing of meniscal tears in young adult goats10.1038/s41598-021-93405-32045-2322https://doaj.org/article/343591bb075046179bda7313a9e4cf522021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93405-3https://doaj.org/toc/2045-2322Abstract Meniscal tears are a common orthopedic injury, yet their healing is difficult to assess post-operatively. This impedes clinical decisions as the healing status of the meniscus cannot be accurately determined non-invasively. Thus, the objectives of this study were to explore the utility of a goat model and to use quantitative magnetic resonance imaging (MRI) techniques, histology, and biomechanical testing to assess the healing status of surgically induced meniscal tears. Adiabatic T1ρ, T2, and T2* relaxation times were quantified for both operated and control menisci ex vivo. Histology was used to assign healing status, assess compositional elements, and associate healing status with compositional elements. Biomechanical testing determined the failure load of healing lesions. Adiabatic T1ρ, T2, and T2* were able to quantitatively identify different healing states. Histology showed evidence of diminished proteoglycans and increased vascularity in both healed and non-healed menisci with surgically induced tears. Biomechanical results revealed that increased healing (as assessed histologically and on MRI) was associated with greater failure load. Our findings indicate increased healing is associated with greater meniscal strength and decreased signal differences (relative to contralateral controls) on MRI. This indicates that quantitative MRI may be a viable method to assess meniscal tears post-operatively.William Fedje-JohnstonCasey P. JohnsonFerenc TóthCathy S. CarlsonArin M. EllingsonMelissa AlbersheimJack LewisJoan BechtoldJutta EllermannAaron RendahlMarc TompkinsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q William Fedje-Johnston Casey P. Johnson Ferenc Tóth Cathy S. Carlson Arin M. Ellingson Melissa Albersheim Jack Lewis Joan Bechtold Jutta Ellermann Aaron Rendahl Marc Tompkins A pilot study to assess the healing of meniscal tears in young adult goats
description	Abstract Meniscal tears are a common orthopedic injury, yet their healing is difficult to assess post-operatively. This impedes clinical decisions as the healing status of the meniscus cannot be accurately determined non-invasively. Thus, the objectives of this study were to explore the utility of a goat model and to use quantitative magnetic resonance imaging (MRI) techniques, histology, and biomechanical testing to assess the healing status of surgically induced meniscal tears. Adiabatic T1ρ, T2, and T2* relaxation times were quantified for both operated and control menisci ex vivo. Histology was used to assign healing status, assess compositional elements, and associate healing status with compositional elements. Biomechanical testing determined the failure load of healing lesions. Adiabatic T1ρ, T2, and T2* were able to quantitatively identify different healing states. Histology showed evidence of diminished proteoglycans and increased vascularity in both healed and non-healed menisci with surgically induced tears. Biomechanical results revealed that increased healing (as assessed histologically and on MRI) was associated with greater failure load. Our findings indicate increased healing is associated with greater meniscal strength and decreased signal differences (relative to contralateral controls) on MRI. This indicates that quantitative MRI may be a viable method to assess meniscal tears post-operatively.
format	article
author	William Fedje-Johnston Casey P. Johnson Ferenc Tóth Cathy S. Carlson Arin M. Ellingson Melissa Albersheim Jack Lewis Joan Bechtold Jutta Ellermann Aaron Rendahl Marc Tompkins
author_facet	William Fedje-Johnston Casey P. Johnson Ferenc Tóth Cathy S. Carlson Arin M. Ellingson Melissa Albersheim Jack Lewis Joan Bechtold Jutta Ellermann Aaron Rendahl Marc Tompkins
author_sort	William Fedje-Johnston
title	A pilot study to assess the healing of meniscal tears in young adult goats
title_short	A pilot study to assess the healing of meniscal tears in young adult goats
title_full	A pilot study to assess the healing of meniscal tears in young adult goats
title_fullStr	A pilot study to assess the healing of meniscal tears in young adult goats
title_full_unstemmed	A pilot study to assess the healing of meniscal tears in young adult goats
title_sort	pilot study to assess the healing of meniscal tears in young adult goats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/343591bb075046179bda7313a9e4cf52
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A pilot study to assess the healing of meniscal tears in young adult goats

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