Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

The unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to imp...

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Autores principales:	Charis Rousou, Carl C. L. Schuurmans, Arto Urtti, Enrico Mastrobattista, Gert Storm, Chrit Moonen, Kai Kaarniranta, Roel Deckers
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ultrasound microbubble drug delivery blood–retina barrier ocular drug delivery USMB Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/34378b0abe5948f2ad711c4b85d6fe61
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spelling	oai:doaj.org-article:34378b0abe5948f2ad711c4b85d6fe612021-11-25T18:40:38ZUltrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application10.3390/pharmaceutics131117821999-4923https://doaj.org/article/34378b0abe5948f2ad711c4b85d6fe612021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1782https://doaj.org/toc/1999-4923The unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to improve the efficacy and targeting of ocular drug delivery. An extensive overview is given of the in vitro and in vivo studies investigating the mechanical effects of ultrasound-driven microbubbles aiming to: (i) temporarily disrupt the blood–retina barrier in order to enhance the delivery of systemically administered drugs into the eye, (ii) induce intracellular uptake of anticancer drugs and macromolecules and (iii) achieve targeted delivery of genes, for the treatment of ocular malignancies and degenerative diseases. Finally, the safety and tolerability aspects of USMB, essential for the translation of USMB to the clinic, are discussed.Charis RousouCarl C. L. SchuurmansArto UrttiEnrico MastrobattistaGert StormChrit MoonenKai KaarnirantaRoel DeckersMDPI AGarticleultrasoundmicrobubbledrug deliveryblood–retina barrierocular drug deliveryUSMBPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1782, p 1782 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ultrasound microbubble drug delivery blood–retina barrier ocular drug delivery USMB Pharmacy and materia medica RS1-441
spellingShingle	ultrasound microbubble drug delivery blood–retina barrier ocular drug delivery USMB Pharmacy and materia medica RS1-441 Charis Rousou Carl C. L. Schuurmans Arto Urtti Enrico Mastrobattista Gert Storm Chrit Moonen Kai Kaarniranta Roel Deckers Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
description	The unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to improve the efficacy and targeting of ocular drug delivery. An extensive overview is given of the in vitro and in vivo studies investigating the mechanical effects of ultrasound-driven microbubbles aiming to: (i) temporarily disrupt the blood–retina barrier in order to enhance the delivery of systemically administered drugs into the eye, (ii) induce intracellular uptake of anticancer drugs and macromolecules and (iii) achieve targeted delivery of genes, for the treatment of ocular malignancies and degenerative diseases. Finally, the safety and tolerability aspects of USMB, essential for the translation of USMB to the clinic, are discussed.
format	article
author	Charis Rousou Carl C. L. Schuurmans Arto Urtti Enrico Mastrobattista Gert Storm Chrit Moonen Kai Kaarniranta Roel Deckers
author_facet	Charis Rousou Carl C. L. Schuurmans Arto Urtti Enrico Mastrobattista Gert Storm Chrit Moonen Kai Kaarniranta Roel Deckers
author_sort	Charis Rousou
title	Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
title_short	Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
title_full	Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
title_fullStr	Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
title_full_unstemmed	Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
title_sort	ultrasound and microbubbles for the treatment of ocular diseases: from preclinical research towards clinical application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/34378b0abe5948f2ad711c4b85d6fe61
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Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application

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