Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct

The mechanisms of formation of the (6-4) photoproducts in DNA damage by sunlight is still debated. Here the authors show, by optical spectroscopies and computations, the details of the formation of a (6-4) photoadduct via the thietane intermediate in a single-stranded DNA oligonucleotide.

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Autores principales:	Luis A. Ortiz-Rodríguez, Christian Reichardt, Sean J. Hoehn, Steffen Jockusch, Carlos E. Crespo-Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/343811f9b7a74c7babd79d0230667245
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spelling	oai:doaj.org-article:343811f9b7a74c7babd79d02306672452021-12-02T18:31:30ZDetection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct10.1038/s41467-020-17333-y2041-1723https://doaj.org/article/343811f9b7a74c7babd79d02306672452020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17333-yhttps://doaj.org/toc/2041-1723The mechanisms of formation of the (6-4) photoproducts in DNA damage by sunlight is still debated. Here the authors show, by optical spectroscopies and computations, the details of the formation of a (6-4) photoadduct via the thietane intermediate in a single-stranded DNA oligonucleotide.Luis A. Ortiz-RodríguezChristian ReichardtSean J. HoehnSteffen JockuschCarlos E. Crespo-HernándezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luis A. Ortiz-Rodríguez Christian Reichardt Sean J. Hoehn Steffen Jockusch Carlos E. Crespo-Hernández Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct
description	The mechanisms of formation of the (6-4) photoproducts in DNA damage by sunlight is still debated. Here the authors show, by optical spectroscopies and computations, the details of the formation of a (6-4) photoadduct via the thietane intermediate in a single-stranded DNA oligonucleotide.
format	article
author	Luis A. Ortiz-Rodríguez Christian Reichardt Sean J. Hoehn Steffen Jockusch Carlos E. Crespo-Hernández
author_facet	Luis A. Ortiz-Rodríguez Christian Reichardt Sean J. Hoehn Steffen Jockusch Carlos E. Crespo-Hernández
author_sort	Luis A. Ortiz-Rodríguez
title	Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct
title_short	Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct
title_full	Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct
title_fullStr	Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct
title_full_unstemmed	Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct
title_sort	detection of the thietane precursor in the uva formation of the dna 6-4 photoadduct
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/343811f9b7a74c7babd79d0230667245
work_keys_str_mv	AT luisaortizrodriguez detectionofthethietaneprecursorintheuvaformationofthedna64photoadduct AT christianreichardt detectionofthethietaneprecursorintheuvaformationofthedna64photoadduct AT seanjhoehn detectionofthethietaneprecursorintheuvaformationofthedna64photoadduct AT steffenjockusch detectionofthethietaneprecursorintheuvaformationofthedna64photoadduct AT carlosecrespohernandez detectionofthethietaneprecursorintheuvaformationofthedna64photoadduct
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Detection of the thietane precursor in the UVA formation of the DNA 6-4 photoadduct

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