Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.

<h4>Background</h4>Torque teno virus (TTV) is a ubiquitous non-pathogenic virus, which is suppressed in immunological healthy individuals but replicates in immune compromised patients. Thus, TTV load is a suitable biomarker for monitoring the immunosuppression also in lung transplant rec...

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Autores principales: Dirk Stefani, Balazs Hegedues, Stephane Collaud, Mohamed Zaatar, Till Ploenes, Daniel Valdivia, Carina Elsner, Barbara Bleekmann, Marek Widera, Ulf Dittmer, Clemens Aigner
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:3438ceb4ca9e4c8e89af9d8cff5090752021-12-02T20:05:20ZTorque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.1932-620310.1371/journal.pone.0252304https://doaj.org/article/3438ceb4ca9e4c8e89af9d8cff5090752021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252304https://doaj.org/toc/1932-6203<h4>Background</h4>Torque teno virus (TTV) is a ubiquitous non-pathogenic virus, which is suppressed in immunological healthy individuals but replicates in immune compromised patients. Thus, TTV load is a suitable biomarker for monitoring the immunosuppression also in lung transplant recipients. Since little is known about the changes of TTV load in lung cancer patients, we analyzed TTV plasma DNA levels in lung cancer patients and its perioperative changes after lung cancer surgery.<h4>Material and methods</h4>Patients with lung cancer and non-malignant nodules as control group were included prospectively. TTV DNA levels were measured by quantiative PCR using DNA isolated from patients plasma and correlated with routine circulating biomarkers and clinicopathological variables.<h4>Results</h4>47 patients (early stage lung cancer n = 30, stage IV lung cancer n = 10, non-malignant nodules n = 7) were included. TTV DNA levels were not detected in seven patients (15%). There was no significant difference between the stage IV cases and the preoperative TTV plasma DNA levels in patients with early stage lung cancer or non-malignant nodules (p = 0.627). While gender, tumor stage and tumor histology showed no correlation with TTV load patients below 65 years of age had a significantly lower TTV load then older patients (p = 0.022). Regarding routine blood based biomarkers, LDH activity was significantly higher in patients with stage IV lung cancer (p = 0.043), however, TTV load showed no correlation with LDH activity, albumin, hemoglobin, CRP or WBC. Comparing the preoperative, postoperative and discharge day TTV load, no unequivocal pattern in the kinetics were.<h4>Conclusion</h4>Our study suggest that lung cancer has no stage dependent impact on TTV plasma DNA levels and confirms that elderly patients have a significantly higher TTV load. Furthermore, we found no uniform perioperative changes during early stage lung cancer resection on plasma TTV DNA levels.Dirk StefaniBalazs HegeduesStephane CollaudMohamed ZaatarTill PloenesDaniel ValdiviaCarina ElsnerBarbara BleekmannMarek WideraUlf DittmerClemens AignerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252304 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Dirk Stefani
Balazs Hegedues
Stephane Collaud
Mohamed Zaatar
Till Ploenes
Daniel Valdivia
Carina Elsner
Barbara Bleekmann
Marek Widera
Ulf Dittmer
Clemens Aigner
Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.
description <h4>Background</h4>Torque teno virus (TTV) is a ubiquitous non-pathogenic virus, which is suppressed in immunological healthy individuals but replicates in immune compromised patients. Thus, TTV load is a suitable biomarker for monitoring the immunosuppression also in lung transplant recipients. Since little is known about the changes of TTV load in lung cancer patients, we analyzed TTV plasma DNA levels in lung cancer patients and its perioperative changes after lung cancer surgery.<h4>Material and methods</h4>Patients with lung cancer and non-malignant nodules as control group were included prospectively. TTV DNA levels were measured by quantiative PCR using DNA isolated from patients plasma and correlated with routine circulating biomarkers and clinicopathological variables.<h4>Results</h4>47 patients (early stage lung cancer n = 30, stage IV lung cancer n = 10, non-malignant nodules n = 7) were included. TTV DNA levels were not detected in seven patients (15%). There was no significant difference between the stage IV cases and the preoperative TTV plasma DNA levels in patients with early stage lung cancer or non-malignant nodules (p = 0.627). While gender, tumor stage and tumor histology showed no correlation with TTV load patients below 65 years of age had a significantly lower TTV load then older patients (p = 0.022). Regarding routine blood based biomarkers, LDH activity was significantly higher in patients with stage IV lung cancer (p = 0.043), however, TTV load showed no correlation with LDH activity, albumin, hemoglobin, CRP or WBC. Comparing the preoperative, postoperative and discharge day TTV load, no unequivocal pattern in the kinetics were.<h4>Conclusion</h4>Our study suggest that lung cancer has no stage dependent impact on TTV plasma DNA levels and confirms that elderly patients have a significantly higher TTV load. Furthermore, we found no uniform perioperative changes during early stage lung cancer resection on plasma TTV DNA levels.
format article
author Dirk Stefani
Balazs Hegedues
Stephane Collaud
Mohamed Zaatar
Till Ploenes
Daniel Valdivia
Carina Elsner
Barbara Bleekmann
Marek Widera
Ulf Dittmer
Clemens Aigner
author_facet Dirk Stefani
Balazs Hegedues
Stephane Collaud
Mohamed Zaatar
Till Ploenes
Daniel Valdivia
Carina Elsner
Barbara Bleekmann
Marek Widera
Ulf Dittmer
Clemens Aigner
author_sort Dirk Stefani
title Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.
title_short Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.
title_full Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.
title_fullStr Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.
title_full_unstemmed Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.
title_sort torque teno virus load in lung cancer patients correlates with age but not with tumor stage.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/3438ceb4ca9e4c8e89af9d8cff509075
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