Mutational bias and the protein code shape the evolution of splicing enhancers

Splicing is regulated by cis-acting elements in pre-mRNAs such as exonic or intronic splicing enhancers and silencers. Here the authors show that exonic splicing enhancers are enriched in exons compared to introns due to mutational bias coupled with purifying selection on the protein code.

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Auteurs principaux:	Stephen Rong, Luke Buerer, Christy L. Rhine, Jing Wang, Kamil J. Cygan, William G. Fairbrother
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3443e38d261c49c28705c2a31a32ed6b
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id	oai:doaj.org-article:3443e38d261c49c28705c2a31a32ed6b
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spelling	oai:doaj.org-article:3443e38d261c49c28705c2a31a32ed6b2021-12-02T17:51:19ZMutational bias and the protein code shape the evolution of splicing enhancers10.1038/s41467-020-16673-z2041-1723https://doaj.org/article/3443e38d261c49c28705c2a31a32ed6b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16673-zhttps://doaj.org/toc/2041-1723Splicing is regulated by cis-acting elements in pre-mRNAs such as exonic or intronic splicing enhancers and silencers. Here the authors show that exonic splicing enhancers are enriched in exons compared to introns due to mutational bias coupled with purifying selection on the protein code.Stephen RongLuke BuererChristy L. RhineJing WangKamil J. CyganWilliam G. FairbrotherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen Rong Luke Buerer Christy L. Rhine Jing Wang Kamil J. Cygan William G. Fairbrother Mutational bias and the protein code shape the evolution of splicing enhancers
description	Splicing is regulated by cis-acting elements in pre-mRNAs such as exonic or intronic splicing enhancers and silencers. Here the authors show that exonic splicing enhancers are enriched in exons compared to introns due to mutational bias coupled with purifying selection on the protein code.
format	article
author	Stephen Rong Luke Buerer Christy L. Rhine Jing Wang Kamil J. Cygan William G. Fairbrother
author_facet	Stephen Rong Luke Buerer Christy L. Rhine Jing Wang Kamil J. Cygan William G. Fairbrother
author_sort	Stephen Rong
title	Mutational bias and the protein code shape the evolution of splicing enhancers
title_short	Mutational bias and the protein code shape the evolution of splicing enhancers
title_full	Mutational bias and the protein code shape the evolution of splicing enhancers
title_fullStr	Mutational bias and the protein code shape the evolution of splicing enhancers
title_full_unstemmed	Mutational bias and the protein code shape the evolution of splicing enhancers
title_sort	mutational bias and the protein code shape the evolution of splicing enhancers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3443e38d261c49c28705c2a31a32ed6b
work_keys_str_mv	AT stephenrong mutationalbiasandtheproteincodeshapetheevolutionofsplicingenhancers AT lukebuerer mutationalbiasandtheproteincodeshapetheevolutionofsplicingenhancers AT christylrhine mutationalbiasandtheproteincodeshapetheevolutionofsplicingenhancers AT jingwang mutationalbiasandtheproteincodeshapetheevolutionofsplicingenhancers AT kamiljcygan mutationalbiasandtheproteincodeshapetheevolutionofsplicingenhancers AT williamgfairbrother mutationalbiasandtheproteincodeshapetheevolutionofsplicingenhancers
_version_	1718379277204848640

Mutational bias and the protein code shape the evolution of splicing enhancers

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