Characteristics of uveitic glaucoma and evaluation of its surgical treatment

Characteristics of uveitic glaucoma and evaluation of its surgical treatment

Ai Shimizu, Kazuichi Maruyama, Yu Yokoyama, Satoru Tsuda, Morin Ryu, Toru Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan Purpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments.Methods: This study ex...

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Autores principales: Shimizu A, Maruyama K, Yokoyama Y, Tsuda S, Ryu M, Nakazawa T
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/34484b17e605431ab2fe4ec3bd807ce9
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spelling oai:doaj.org-article:34484b17e605431ab2fe4ec3bd807ce92021-12-02T04:33:41ZCharacteristics of uveitic glaucoma and evaluation of its surgical treatment1177-5483https://doaj.org/article/34484b17e605431ab2fe4ec3bd807ce92014-11-01T00:00:00Zhttp://www.dovepress.com/characteristics-of-uveitic-glaucoma-and-evaluation-of-its-surgical-tre-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Ai Shimizu, Kazuichi Maruyama, Yu Yokoyama, Satoru Tsuda, Morin Ryu, Toru Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan Purpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments.Methods: This study examined a retrospective, nonrandomized comparative interventional case series of 105 UG patients (141 eyes) followed between April 1, 2001 and July 30, 2014 at the outpatient clinic of Tohoku University Hospital. The study group included 47 patients (47 eyes) who underwent glaucoma surgery: trabeculectomy, trabeculotomy, and trabectome surgery. The analysis used Kaplan–Meier life tables, with surgical failure defined as intraocular pressure ≧21 mmHg or the need for additional glaucoma surgery.Results: UG patients represented 9.73% of our database of glaucoma patients. The mean follow-up period was 40.32±32.53 months. Seventy-one patients had granulomatous uveitis (67.62%) and 34 had nongranulomatous uveitis (32.38%). The causes of uveitis included sarcoidosis (n=25), Behçet’s disease (n=11), Vogt–Koyanagi–Harada disease (n=9), Posner–Schlossman syndrome (n=12), herpes simplex virus infectious uveitis (n=7), acute anterior uveitis (n=5), intermediate uveitis (n=4), scleritis (n=4), inflammatory bowel disease (n=4), varicella zoster virus uveitis (n=2), and others (n=6). An additional 16 patients were diagnosed with idiopathic UG. Surgical success rates were 82.86% for trabeculectomy, 62.50% for trabeculotomy, and 75.00% for trabectome. Significant risk factors for surgical failure included male sex (P=0.02), age less than 45 years (P=0.0009), nongranulomatous uveitis (P=0.04), and postoperative inflammation (P=0.01).Conclusion: Young male patients with nongranulomatous uveitis had a significant risk of surgical failure. Moreover, prolonged postoperative inflammation created a susceptibility to surgical failure, indicating the importance of postoperative inflammation reduction. Keywords: uveitic glaucoma, sarcoidosis, Behçet’s diseaseShimizu AMaruyama KYokoyama YTsuda SRyu MNakazawa TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2383-2389 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Shimizu A
Maruyama K
Yokoyama Y
Tsuda S
Ryu M
Nakazawa T
Characteristics of uveitic glaucoma and evaluation of its surgical treatment
description Ai Shimizu, Kazuichi Maruyama, Yu Yokoyama, Satoru Tsuda, Morin Ryu, Toru Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan Purpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments.Methods: This study examined a retrospective, nonrandomized comparative interventional case series of 105 UG patients (141 eyes) followed between April 1, 2001 and July 30, 2014 at the outpatient clinic of Tohoku University Hospital. The study group included 47 patients (47 eyes) who underwent glaucoma surgery: trabeculectomy, trabeculotomy, and trabectome surgery. The analysis used Kaplan–Meier life tables, with surgical failure defined as intraocular pressure ≧21 mmHg or the need for additional glaucoma surgery.Results: UG patients represented 9.73% of our database of glaucoma patients. The mean follow-up period was 40.32±32.53 months. Seventy-one patients had granulomatous uveitis (67.62%) and 34 had nongranulomatous uveitis (32.38%). The causes of uveitis included sarcoidosis (n=25), Behçet’s disease (n=11), Vogt–Koyanagi–Harada disease (n=9), Posner–Schlossman syndrome (n=12), herpes simplex virus infectious uveitis (n=7), acute anterior uveitis (n=5), intermediate uveitis (n=4), scleritis (n=4), inflammatory bowel disease (n=4), varicella zoster virus uveitis (n=2), and others (n=6). An additional 16 patients were diagnosed with idiopathic UG. Surgical success rates were 82.86% for trabeculectomy, 62.50% for trabeculotomy, and 75.00% for trabectome. Significant risk factors for surgical failure included male sex (P=0.02), age less than 45 years (P=0.0009), nongranulomatous uveitis (P=0.04), and postoperative inflammation (P=0.01).Conclusion: Young male patients with nongranulomatous uveitis had a significant risk of surgical failure. Moreover, prolonged postoperative inflammation created a susceptibility to surgical failure, indicating the importance of postoperative inflammation reduction. Keywords: uveitic glaucoma, sarcoidosis, Behçet’s disease
format article
author Shimizu A
Maruyama K
Yokoyama Y
Tsuda S
Ryu M
Nakazawa T
author_facet Shimizu A
Maruyama K
Yokoyama Y
Tsuda S
Ryu M
Nakazawa T
author_sort Shimizu A
title Characteristics of uveitic glaucoma and evaluation of its surgical treatment
title_short Characteristics of uveitic glaucoma and evaluation of its surgical treatment
title_full Characteristics of uveitic glaucoma and evaluation of its surgical treatment
title_fullStr Characteristics of uveitic glaucoma and evaluation of its surgical treatment
title_full_unstemmed Characteristics of uveitic glaucoma and evaluation of its surgical treatment
title_sort characteristics of uveitic glaucoma and evaluation of its surgical treatment
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/34484b17e605431ab2fe4ec3bd807ce9
work_keys_str_mv AT shimizua characteristicsofuveiticglaucomaandevaluationofitssurgicaltreatment
AT maruyamak characteristicsofuveiticglaucomaandevaluationofitssurgicaltreatment
AT yokoyamay characteristicsofuveiticglaucomaandevaluationofitssurgicaltreatment
AT tsudas characteristicsofuveiticglaucomaandevaluationofitssurgicaltreatment
AT ryum characteristicsofuveiticglaucomaandevaluationofitssurgicaltreatment
AT nakazawat characteristicsofuveiticglaucomaandevaluationofitssurgicaltreatment
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