Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates.

The high molecular weight, multidomain VAR2CSA protein mediating adhesion of Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a pregnancy malaria vaccine. However, it has been difficult so far to generate strong and consistent adhesion blocking antibody respon...

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Autores principales: Marion Avril, Marianne J Hathaway, Anand Srivastava, Sébastien Dechavanne, Mirja Hommel, James G Beeson, Joseph D Smith, Benoît Gamain
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/34488d96197a41ceb3b5616c494c6798
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