Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent

Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that pois...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kim Sneppen, Leonie Ringrose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/344a9aa5671646888fbae5c488d5080b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:344a9aa5671646888fbae5c488d5080b
record_format	dspace
spelling	oai:doaj.org-article:344a9aa5671646888fbae5c488d5080b2021-12-02T16:57:40ZTheoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent10.1038/s41467-019-10130-22041-1723https://doaj.org/article/344a9aa5671646888fbae5c488d5080b2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10130-2https://doaj.org/toc/2041-1723Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as previously proposed, but is bistable, meaning that the system switches frequently between stable active and silent states.Kim SneppenLeonie RingroseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kim Sneppen Leonie Ringrose Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
description	Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as previously proposed, but is bistable, meaning that the system switches frequently between stable active and silent states.
format	article
author	Kim Sneppen Leonie Ringrose
author_facet	Kim Sneppen Leonie Ringrose
author_sort	Kim Sneppen
title	Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
title_short	Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
title_full	Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
title_fullStr	Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
title_full_unstemmed	Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
title_sort	theoretical analysis of polycomb-trithorax systems predicts that poised chromatin is bistable and not bivalent
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/344a9aa5671646888fbae5c488d5080b
work_keys_str_mv	AT kimsneppen theoreticalanalysisofpolycombtrithoraxsystemspredictsthatpoisedchromatinisbistableandnotbivalent AT leonieringrose theoreticalanalysisofpolycombtrithoraxsystemspredictsthatpoisedchromatinisbistableandnotbivalent
_version_	1718382493896278016

Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent

Ejemplares similares