Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.

<h4>Background</h4>Metastasis to regional lymph nodes via lymphatic vessels plays a key role in cancer progression. Tumor lymphangiogenesis is known to promote lymphatic metastasis, and vascular endothelial growth factor C (VEGF-C) is a critical activator of tumor lymphangiogenesis durin...

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Autores principales:	Yasusei Kudo, Shinji Iizuka, Maki Yoshida, Phuong Thao Nguyen, Samadarani B S M Siriwardena, Takaaki Tsunematsu, Mariko Ohbayashi, Toshinori Ando, Daijiro Hatakeyama, Toshiyuki Shibata, Keiichi Koizumi, Masahiro Maeda, Naozumi Ishimaru, Ikuko Ogawa, Takashi Takata
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/344cc933877e446aa82bef6379cb25c2
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spelling	oai:doaj.org-article:344cc933877e446aa82bef6379cb25c22021-11-18T07:06:59ZPeriostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.1932-620310.1371/journal.pone.0044488https://doaj.org/article/344cc933877e446aa82bef6379cb25c22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952986/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Metastasis to regional lymph nodes via lymphatic vessels plays a key role in cancer progression. Tumor lymphangiogenesis is known to promote lymphatic metastasis, and vascular endothelial growth factor C (VEGF-C) is a critical activator of tumor lymphangiogenesis during the process of metastasis. We previously identified periostin as an invasion- and angiogenesis-promoting factor in head and neck squamous cell carcinoma (HNSCC). In this study, we discovered a novel role for periostin in tumor lymphangiogenesis.<h4>Methods and findings</h4>Periostin overexpression upregulated VEGF-C mRNA expression in HNSCC cells. By using conditioned media from periostin-overexpressing HNSCC cells, we examined tube formation of lymphatic endothelial cells. Conditioned media from periostin-overexpressing cells promoted tube formation. To know the correlation between periostin and VEGF-C, we compared Periostin expression with VEGF-C expression in 54 HNSCC cases by immunohistochemistry. Periostin expression was correlated well with VEGF-C expression in HNSCC cases. Moreover, correlation between periostin and VEGF-C secretion was observed in serum from HNSCC patients. Interestingly, periostin itself promoted tube formation of lymphatic endothelial cells independently of VEGF-C. Periostin-promoted lymphangiogenesis was mediated by Src and Akt activity. Indeed possible correlation between periostin and lymphatic status in periostin-overexpressing xenograft tumors and HNSCC cases was observed.<h4>Conclusions</h4>Our findings suggest that periostin itself as well as periostin-induced upregulation of VEGF-C may promote lymphangiogenesis. We suggest that periostin may be a marker for prediction of malignant behaviors in HNSCC and a potential target for future therapeutic intervention to obstruct tumoral lymphatic invasion and lymphangiogenesis in HNSCC patients.Yasusei KudoShinji IizukaMaki YoshidaPhuong Thao NguyenSamadarani B S M SiriwardenaTakaaki TsunematsuMariko OhbayashiToshinori AndoDaijiro HatakeyamaToshiyuki ShibataKeiichi KoizumiMasahiro MaedaNaozumi IshimaruIkuko OgawaTakashi TakataPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e44488 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasusei Kudo Shinji Iizuka Maki Yoshida Phuong Thao Nguyen Samadarani B S M Siriwardena Takaaki Tsunematsu Mariko Ohbayashi Toshinori Ando Daijiro Hatakeyama Toshiyuki Shibata Keiichi Koizumi Masahiro Maeda Naozumi Ishimaru Ikuko Ogawa Takashi Takata Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.
description	<h4>Background</h4>Metastasis to regional lymph nodes via lymphatic vessels plays a key role in cancer progression. Tumor lymphangiogenesis is known to promote lymphatic metastasis, and vascular endothelial growth factor C (VEGF-C) is a critical activator of tumor lymphangiogenesis during the process of metastasis. We previously identified periostin as an invasion- and angiogenesis-promoting factor in head and neck squamous cell carcinoma (HNSCC). In this study, we discovered a novel role for periostin in tumor lymphangiogenesis.<h4>Methods and findings</h4>Periostin overexpression upregulated VEGF-C mRNA expression in HNSCC cells. By using conditioned media from periostin-overexpressing HNSCC cells, we examined tube formation of lymphatic endothelial cells. Conditioned media from periostin-overexpressing cells promoted tube formation. To know the correlation between periostin and VEGF-C, we compared Periostin expression with VEGF-C expression in 54 HNSCC cases by immunohistochemistry. Periostin expression was correlated well with VEGF-C expression in HNSCC cases. Moreover, correlation between periostin and VEGF-C secretion was observed in serum from HNSCC patients. Interestingly, periostin itself promoted tube formation of lymphatic endothelial cells independently of VEGF-C. Periostin-promoted lymphangiogenesis was mediated by Src and Akt activity. Indeed possible correlation between periostin and lymphatic status in periostin-overexpressing xenograft tumors and HNSCC cases was observed.<h4>Conclusions</h4>Our findings suggest that periostin itself as well as periostin-induced upregulation of VEGF-C may promote lymphangiogenesis. We suggest that periostin may be a marker for prediction of malignant behaviors in HNSCC and a potential target for future therapeutic intervention to obstruct tumoral lymphatic invasion and lymphangiogenesis in HNSCC patients.
format	article
author	Yasusei Kudo Shinji Iizuka Maki Yoshida Phuong Thao Nguyen Samadarani B S M Siriwardena Takaaki Tsunematsu Mariko Ohbayashi Toshinori Ando Daijiro Hatakeyama Toshiyuki Shibata Keiichi Koizumi Masahiro Maeda Naozumi Ishimaru Ikuko Ogawa Takashi Takata
author_facet	Yasusei Kudo Shinji Iizuka Maki Yoshida Phuong Thao Nguyen Samadarani B S M Siriwardena Takaaki Tsunematsu Mariko Ohbayashi Toshinori Ando Daijiro Hatakeyama Toshiyuki Shibata Keiichi Koizumi Masahiro Maeda Naozumi Ishimaru Ikuko Ogawa Takashi Takata
author_sort	Yasusei Kudo
title	Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.
title_short	Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.
title_full	Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.
title_fullStr	Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.
title_full_unstemmed	Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.
title_sort	periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/344cc933877e446aa82bef6379cb25c2
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Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.

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