Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.

<h4>Introduction</h4>Shigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs). Knowledge on naturally acquired immunity can support the development of Shigella candidate vaccines mostly needed in LM...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caroline C Chisenga, Samuel Bosomprah, Michelo Simuyandi, Katayi Mwila-Kazimbaya, Obvious N Chilyabanyama, Natasha M Laban, Anya Bialik, Valeria Asato, Shiri Meron-Sudai, Gad Frankel, Daniel Cohen, Roma Chilengi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/344fea9a3c4a4a649cec3078ee335959
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:344fea9a3c4a4a649cec3078ee335959
record_format	dspace
spelling	oai:doaj.org-article:344fea9a3c4a4a649cec3078ee3359592021-11-25T06:23:41ZShigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.1932-620310.1371/journal.pone.0252222https://doaj.org/article/344fea9a3c4a4a649cec3078ee3359592021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252222https://doaj.org/toc/1932-6203<h4>Introduction</h4>Shigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs). Knowledge on naturally acquired immunity can support the development of Shigella candidate vaccines mostly needed in LMICs. We aimed to quantify Shigella-specific antibodies of maternal origin and those naturally acquired in Zambian infants.<h4>Methods</h4>Plasma samples collected from infants at age 6, 14 and 52-weeks were tested for Shigella (S. sonnei and S. flexneri 2a) lipopolysaccharide (LPS) antigen specific immunoglobulin G (IgG) and A (IgA) by enzyme-linked immunosorbent assay.<h4>Results</h4>At 6 weeks infant age, the IgG geometric mean titres (GMT) against S. sonnei (N = 159) and S. flexneri 2a (N = 135) LPS were 311 (95% CI 259-372) and 446 (95% CI 343-580) respectively. By 14 weeks, a decline in IgG GMT was observed for both S. sonnei to 104 (95% CI 88-124), and S. flexneri 2a to 183 (95% CI 147-230). Both S. sonnei and S. flexneri 2a specific IgG GMT continued to decrease by 52 weeks infant age when compared to 6 weeks. In 27% and 8% of infants a significant rise in titre (4 fold and greater) against S. flexneri 2a and S. sonnei LPS, respectively, was detected between the ages of 14 and 52 weeks. IgA levels against both species LPS were very low at 6 and 14 weeks and raised significantly against S. flexneri 2a and S. sonnei LPS in 29% and 10% of the infants, respectively.<h4>Conclusion</h4>In our setting, transplacental IgG anti-Shigella LPS is present at high levels in early infancy, and begins to decrease by age 14 weeks. Our results are consistent with early exposure to Shigella and indicate naturally acquired IgG and IgA antibodies to S. flexneri 2a and S. sonnei LPS in part of infants between 14 and 52 weeks of age. These results suggest that a potential timing of vaccination would be after 14 and before 52 weeks of age to ensure early infant protection against shigellosis.Caroline C ChisengaSamuel BosomprahMichelo SimuyandiKatayi Mwila-KazimbayaObvious N ChilyabanyamaNatasha M LabanAnya BialikValeria AsatoShiri Meron-SudaiGad FrankelDaniel CohenRoma ChilengiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0252222 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline C Chisenga Samuel Bosomprah Michelo Simuyandi Katayi Mwila-Kazimbaya Obvious N Chilyabanyama Natasha M Laban Anya Bialik Valeria Asato Shiri Meron-Sudai Gad Frankel Daniel Cohen Roma Chilengi Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.
description	<h4>Introduction</h4>Shigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs). Knowledge on naturally acquired immunity can support the development of Shigella candidate vaccines mostly needed in LMICs. We aimed to quantify Shigella-specific antibodies of maternal origin and those naturally acquired in Zambian infants.<h4>Methods</h4>Plasma samples collected from infants at age 6, 14 and 52-weeks were tested for Shigella (S. sonnei and S. flexneri 2a) lipopolysaccharide (LPS) antigen specific immunoglobulin G (IgG) and A (IgA) by enzyme-linked immunosorbent assay.<h4>Results</h4>At 6 weeks infant age, the IgG geometric mean titres (GMT) against S. sonnei (N = 159) and S. flexneri 2a (N = 135) LPS were 311 (95% CI 259-372) and 446 (95% CI 343-580) respectively. By 14 weeks, a decline in IgG GMT was observed for both S. sonnei to 104 (95% CI 88-124), and S. flexneri 2a to 183 (95% CI 147-230). Both S. sonnei and S. flexneri 2a specific IgG GMT continued to decrease by 52 weeks infant age when compared to 6 weeks. In 27% and 8% of infants a significant rise in titre (4 fold and greater) against S. flexneri 2a and S. sonnei LPS, respectively, was detected between the ages of 14 and 52 weeks. IgA levels against both species LPS were very low at 6 and 14 weeks and raised significantly against S. flexneri 2a and S. sonnei LPS in 29% and 10% of the infants, respectively.<h4>Conclusion</h4>In our setting, transplacental IgG anti-Shigella LPS is present at high levels in early infancy, and begins to decrease by age 14 weeks. Our results are consistent with early exposure to Shigella and indicate naturally acquired IgG and IgA antibodies to S. flexneri 2a and S. sonnei LPS in part of infants between 14 and 52 weeks of age. These results suggest that a potential timing of vaccination would be after 14 and before 52 weeks of age to ensure early infant protection against shigellosis.
format	article
author	Caroline C Chisenga Samuel Bosomprah Michelo Simuyandi Katayi Mwila-Kazimbaya Obvious N Chilyabanyama Natasha M Laban Anya Bialik Valeria Asato Shiri Meron-Sudai Gad Frankel Daniel Cohen Roma Chilengi
author_facet	Caroline C Chisenga Samuel Bosomprah Michelo Simuyandi Katayi Mwila-Kazimbaya Obvious N Chilyabanyama Natasha M Laban Anya Bialik Valeria Asato Shiri Meron-Sudai Gad Frankel Daniel Cohen Roma Chilengi
author_sort	Caroline C Chisenga
title	Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.
title_short	Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.
title_full	Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.
title_fullStr	Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.
title_full_unstemmed	Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.
title_sort	shigella-specific antibodies in the first year of life among zambian infants: a longitudinal cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/344fea9a3c4a4a649cec3078ee335959
work_keys_str_mv	AT carolinecchisenga shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT samuelbosomprah shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT michelosimuyandi shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT katayimwilakazimbaya shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT obviousnchilyabanyama shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT natashamlaban shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT anyabialik shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT valeriaasato shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT shirimeronsudai shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT gadfrankel shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT danielcohen shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy AT romachilengi shigellaspecificantibodiesinthefirstyearoflifeamongzambianinfantsalongitudinalcohortstudy
_version_	1718413734045548544

Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.

Ejemplares similares