Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.

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Autores principales:	Sunil V. Sharma, Xiaoxue Tong, Cristina Pubill-Ulldemolins, Christopher Cartmell, Emma J. A. Bogosyan, Emma J. Rackham, Enrico Marelli, Refaat B. Hamed, Rebecca J. M. Goss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/345055a2bdf74d8e90c9a96c8f5dc70e
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spelling	oai:doaj.org-article:345055a2bdf74d8e90c9a96c8f5dc70e2021-12-02T14:16:47ZLiving GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo10.1038/s41467-017-00194-32041-1723https://doaj.org/article/345055a2bdf74d8e90c9a96c8f5dc70e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00194-3https://doaj.org/toc/2041-1723Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.Sunil V. SharmaXiaoxue TongCristina Pubill-UlldemolinsChristopher CartmellEmma J. A. BogosyanEmma J. RackhamEnrico MarelliRefaat B. HamedRebecca J. M. GossNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sunil V. Sharma Xiaoxue Tong Cristina Pubill-Ulldemolins Christopher Cartmell Emma J. A. Bogosyan Emma J. Rackham Enrico Marelli Refaat B. Hamed Rebecca J. M. Goss Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
description	Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.
format	article
author	Sunil V. Sharma Xiaoxue Tong Cristina Pubill-Ulldemolins Christopher Cartmell Emma J. A. Bogosyan Emma J. Rackham Enrico Marelli Refaat B. Hamed Rebecca J. M. Goss
author_facet	Sunil V. Sharma Xiaoxue Tong Cristina Pubill-Ulldemolins Christopher Cartmell Emma J. A. Bogosyan Emma J. Rackham Enrico Marelli Refaat B. Hamed Rebecca J. M. Goss
author_sort	Sunil V. Sharma
title	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_short	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_full	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_fullStr	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_full_unstemmed	Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
title_sort	living genochemetics by hyphenating synthetic biology and synthetic chemistry in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/345055a2bdf74d8e90c9a96c8f5dc70e
work_keys_str_mv	AT sunilvsharma livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT xiaoxuetong livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT cristinapubillulldemolins livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT christophercartmell livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT emmajabogosyan livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT emmajrackham livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT enricomarelli livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT refaatbhamed livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo AT rebeccajmgoss livinggenochemeticsbyhyphenatingsyntheticbiologyandsyntheticchemistryinvivo
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Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

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