Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

Coupling synthetic biology and chemical reactions in cells is a challenging task. The authors engineer bacteria capable of generating bromo-metabolites, develop a mild Suzuki-Miyaura cross-coupling reaction compatible with cell growth and carry out the cross-coupling chemistry in live cell cultures.

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Bibliographic Details
Main Authors: Sunil V. Sharma, Xiaoxue Tong, Cristina Pubill-Ulldemolins, Christopher Cartmell, Emma J. A. Bogosyan, Emma J. Rackham, Enrico Marelli, Refaat B. Hamed, Rebecca J. M. Goss
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/345055a2bdf74d8e90c9a96c8f5dc70e
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