EEF1A1 deacetylation enables transcriptional activation of remyelination

The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and increasing remyelination efficiency.

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Autores principales:	Mert Duman, Adrien Vaquié, Gianluigi Nocera, Manfred Heller, Michael Stumpe, Devanarayanan Siva Sankar, Jörn Dengjel, Dies Meijer, Teppei Yamaguchi, Patrick Matthias, Thomas Zeis, Nicole Schaeren-Wiemers, Antoinette Hayoz, Sophie Ruff, Claire Jacob
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/345079c66c764f6ca5ac313e500b3117
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spelling	oai:doaj.org-article:345079c66c764f6ca5ac313e500b31172021-12-02T15:39:52ZEEF1A1 deacetylation enables transcriptional activation of remyelination10.1038/s41467-020-17243-z2041-1723https://doaj.org/article/345079c66c764f6ca5ac313e500b31172020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17243-zhttps://doaj.org/toc/2041-1723The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and increasing remyelination efficiency.Mert DumanAdrien VaquiéGianluigi NoceraManfred HellerMichael StumpeDevanarayanan Siva SankarJörn DengjelDies MeijerTeppei YamaguchiPatrick MatthiasThomas ZeisNicole Schaeren-WiemersAntoinette HayozSophie RuffClaire JacobNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mert Duman Adrien Vaquié Gianluigi Nocera Manfred Heller Michael Stumpe Devanarayanan Siva Sankar Jörn Dengjel Dies Meijer Teppei Yamaguchi Patrick Matthias Thomas Zeis Nicole Schaeren-Wiemers Antoinette Hayoz Sophie Ruff Claire Jacob EEF1A1 deacetylation enables transcriptional activation of remyelination
description	The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and increasing remyelination efficiency.
format	article
author	Mert Duman Adrien Vaquié Gianluigi Nocera Manfred Heller Michael Stumpe Devanarayanan Siva Sankar Jörn Dengjel Dies Meijer Teppei Yamaguchi Patrick Matthias Thomas Zeis Nicole Schaeren-Wiemers Antoinette Hayoz Sophie Ruff Claire Jacob
author_facet	Mert Duman Adrien Vaquié Gianluigi Nocera Manfred Heller Michael Stumpe Devanarayanan Siva Sankar Jörn Dengjel Dies Meijer Teppei Yamaguchi Patrick Matthias Thomas Zeis Nicole Schaeren-Wiemers Antoinette Hayoz Sophie Ruff Claire Jacob
author_sort	Mert Duman
title	EEF1A1 deacetylation enables transcriptional activation of remyelination
title_short	EEF1A1 deacetylation enables transcriptional activation of remyelination
title_full	EEF1A1 deacetylation enables transcriptional activation of remyelination
title_fullStr	EEF1A1 deacetylation enables transcriptional activation of remyelination
title_full_unstemmed	EEF1A1 deacetylation enables transcriptional activation of remyelination
title_sort	eef1a1 deacetylation enables transcriptional activation of remyelination
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/345079c66c764f6ca5ac313e500b3117
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EEF1A1 deacetylation enables transcriptional activation of remyelination

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