Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics

Context Bupleuri Radix, the dried root of Bupleurum chinense DC and Bupleurum scorzonerifolium Willd (Apiaceae), is an important medicinal herb widely used to treat cancers for hundreds of years in Asian countries. As the most antitumour component but also the main toxic component in Bupleuri Radix,...

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Autores principales:	Piao Zhou, Wei Shi, Xiao-Yan He, Quan-Yu Du, Fei Wang, Jing Guo
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	bupleuri radix saikosaponins phytochemicals tumour mechanisms cytotoxicity metabolism Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3452963159d247e4b7a964c134bfa7ee
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spelling	oai:doaj.org-article:3452963159d247e4b7a964c134bfa7ee2021-11-04T15:00:42ZSaikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics1388-02091744-511610.1080/13880209.2021.1992448https://doaj.org/article/3452963159d247e4b7a964c134bfa7ee2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2021.1992448https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context Bupleuri Radix, the dried root of Bupleurum chinense DC and Bupleurum scorzonerifolium Willd (Apiaceae), is an important medicinal herb widely used to treat cancers for hundreds of years in Asian countries. As the most antitumour component but also the main toxic component in Bupleuri Radix, saikosaponin D (SSD) has attracted extensive attention. However, no summary studies have been reported on the antitumour effects, toxicity and pharmacokinetics of this potential natural anticancer substance. Objective To analyse and summarise the existing findings regarding to the antitumour effects, toxicity and pharmacokinetics of SSD. Materials and methods We collected relevant information published before April 2021 by conducting a search of literature available in various online databases including PubMed, Science Direct, CNKI, Wanfang database and the Chinese Biological Medicine Database. Bupleurum, Bupleuri Radix, saikosaponin, saikosaponin D, tumour, toxicity, and pharmacokinetics were used as the keywords. Results The antitumour effects of SSD were multi-targeted and can be realised through various mechanisms, including inhibition of proliferation, invasion, metastasis and angiogenesis, as well as induction of cell apoptosis, autophagy, and differentiation. The toxicological effects of SSD mainly included hepatotoxicity, neurotoxicity, haemolysis and cardiotoxicity. Pharmacokinetic studies demonstrated that SSD had the potential to alter the pharmacokinetics of some drugs for its influence on CYPs and P-gp, and the oral bioavailability and actual pharmacodynamic substances in vivo of SSD are still controversial. Conclusions SSD is a potentially effective and relatively safe natural antitumour substance, but more research is needed, especially in vivo antitumour effects and pharmacokinetics of the compound.Piao ZhouWei ShiXiao-Yan HeQuan-Yu DuFei WangJing GuoTaylor & Francis Grouparticlebupleuri radixsaikosaponinsphytochemicalstumourmechanismscytotoxicitymetabolismTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 59, Iss 1, Pp 1480-1489 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bupleuri radix saikosaponins phytochemicals tumour mechanisms cytotoxicity metabolism Therapeutics. Pharmacology RM1-950
spellingShingle	bupleuri radix saikosaponins phytochemicals tumour mechanisms cytotoxicity metabolism Therapeutics. Pharmacology RM1-950 Piao Zhou Wei Shi Xiao-Yan He Quan-Yu Du Fei Wang Jing Guo Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
description	Context Bupleuri Radix, the dried root of Bupleurum chinense DC and Bupleurum scorzonerifolium Willd (Apiaceae), is an important medicinal herb widely used to treat cancers for hundreds of years in Asian countries. As the most antitumour component but also the main toxic component in Bupleuri Radix, saikosaponin D (SSD) has attracted extensive attention. However, no summary studies have been reported on the antitumour effects, toxicity and pharmacokinetics of this potential natural anticancer substance. Objective To analyse and summarise the existing findings regarding to the antitumour effects, toxicity and pharmacokinetics of SSD. Materials and methods We collected relevant information published before April 2021 by conducting a search of literature available in various online databases including PubMed, Science Direct, CNKI, Wanfang database and the Chinese Biological Medicine Database. Bupleurum, Bupleuri Radix, saikosaponin, saikosaponin D, tumour, toxicity, and pharmacokinetics were used as the keywords. Results The antitumour effects of SSD were multi-targeted and can be realised through various mechanisms, including inhibition of proliferation, invasion, metastasis and angiogenesis, as well as induction of cell apoptosis, autophagy, and differentiation. The toxicological effects of SSD mainly included hepatotoxicity, neurotoxicity, haemolysis and cardiotoxicity. Pharmacokinetic studies demonstrated that SSD had the potential to alter the pharmacokinetics of some drugs for its influence on CYPs and P-gp, and the oral bioavailability and actual pharmacodynamic substances in vivo of SSD are still controversial. Conclusions SSD is a potentially effective and relatively safe natural antitumour substance, but more research is needed, especially in vivo antitumour effects and pharmacokinetics of the compound.
format	article
author	Piao Zhou Wei Shi Xiao-Yan He Quan-Yu Du Fei Wang Jing Guo
author_facet	Piao Zhou Wei Shi Xiao-Yan He Quan-Yu Du Fei Wang Jing Guo
author_sort	Piao Zhou
title	Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
title_short	Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
title_full	Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
title_fullStr	Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
title_full_unstemmed	Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
title_sort	saikosaponin d: review on the antitumour effects, toxicity and pharmacokinetics
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/3452963159d247e4b7a964c134bfa7ee
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Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics

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