Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence

Linlin Yang, Xiaochuan Zhao, Lan Wang, Lulu Yu, Mei Song, Xueyi Wang Department of Mental Health, The First Hospital of Hebei Medical University, Hebei Medical University Institute of Mental Health, Shijiazhuang, People’s Republic of China Abstract: Amnestic mild cognitive impai...

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Autores principales:	Yang L, Zhao X, Wang L, Yu L, Song M, Wang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/34531008b3f54fa4907d9367c0fc30f9
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spelling	oai:doaj.org-article:34531008b3f54fa4907d9367c0fc30f92021-12-02T01:25:51ZEmotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence1178-2021https://doaj.org/article/34531008b3f54fa4907d9367c0fc30f92015-08-01T00:00:00Zhttp://www.dovepress.com/emotional-face-recognition-deficit-in-amnestic-patients-with-mild-cogn-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Linlin Yang, Xiaochuan Zhao, Lan Wang, Lulu Yu, Mei Song, Xueyi Wang Department of Mental Health, The First Hospital of Hebei Medical University, Hebei Medical University Institute of Mental Health, Shijiazhuang, People’s Republic of China Abstract: Amnestic mild cognitive impairment (MCI) has been conceptualized as a transitional stage between healthy aging and Alzheimer’s disease. Thus, understanding emotional face recognition deficit in patients with amnestic MCI could be useful in determining progression of amnestic MCI. The purpose of this study was to investigate the features of emotional face processing in amnestic MCI by using event-related potentials (ERPs). Patients with amnestic MCI and healthy controls performed a face recognition task, giving old/new responses to previously studied and novel faces with different emotional messages as the stimulus material. Using the learning-recognition paradigm, the experiments were divided into two steps, ie, a learning phase and a test phase. ERPs were analyzed on electroencephalographic recordings. The behavior data indicated high emotion classification accuracy for patients with amnestic MCI and for healthy controls. The mean percentage of correct classifications was 81.19% for patients with amnestic MCI and 96.46% for controls. Our ERP data suggest that patients with amnestic MCI were still be able to undertake personalizing processing for negative faces, but not for neutral or positive faces, in the early frontal processing stage. In the early time window, no differences in frontal old/new effect were found between patients with amnestic MCI and normal controls. However, in the late time window, the three types of stimuli did not elicit any old/new parietal effects in patients with amnestic MCI, suggesting their recollection was impaired. This impairment may be closely associated with amnestic MCI disease. We conclude from our data that face recognition processing and emotional memory is impaired in patients with amnestic MCI. Such damage mainly occurred in the early coding stages. In addition, we found that patients with amnestic MCI had difficulty in post-processing of positive and neutral facial emotions. Keywords: event-related potential, emotion, recognition memory, amnestic mild cognitive impairment, facesYang LZhao XWang LYu LSong MWang XDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1973-1987 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yang L Zhao X Wang L Yu L Song M Wang X Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence
description	Linlin Yang, Xiaochuan Zhao, Lan Wang, Lulu Yu, Mei Song, Xueyi Wang Department of Mental Health, The First Hospital of Hebei Medical University, Hebei Medical University Institute of Mental Health, Shijiazhuang, People’s Republic of China Abstract: Amnestic mild cognitive impairment (MCI) has been conceptualized as a transitional stage between healthy aging and Alzheimer’s disease. Thus, understanding emotional face recognition deficit in patients with amnestic MCI could be useful in determining progression of amnestic MCI. The purpose of this study was to investigate the features of emotional face processing in amnestic MCI by using event-related potentials (ERPs). Patients with amnestic MCI and healthy controls performed a face recognition task, giving old/new responses to previously studied and novel faces with different emotional messages as the stimulus material. Using the learning-recognition paradigm, the experiments were divided into two steps, ie, a learning phase and a test phase. ERPs were analyzed on electroencephalographic recordings. The behavior data indicated high emotion classification accuracy for patients with amnestic MCI and for healthy controls. The mean percentage of correct classifications was 81.19% for patients with amnestic MCI and 96.46% for controls. Our ERP data suggest that patients with amnestic MCI were still be able to undertake personalizing processing for negative faces, but not for neutral or positive faces, in the early frontal processing stage. In the early time window, no differences in frontal old/new effect were found between patients with amnestic MCI and normal controls. However, in the late time window, the three types of stimuli did not elicit any old/new parietal effects in patients with amnestic MCI, suggesting their recollection was impaired. This impairment may be closely associated with amnestic MCI disease. We conclude from our data that face recognition processing and emotional memory is impaired in patients with amnestic MCI. Such damage mainly occurred in the early coding stages. In addition, we found that patients with amnestic MCI had difficulty in post-processing of positive and neutral facial emotions. Keywords: event-related potential, emotion, recognition memory, amnestic mild cognitive impairment, faces
format	article
author	Yang L Zhao X Wang L Yu L Song M Wang X
author_facet	Yang L Zhao X Wang L Yu L Song M Wang X
author_sort	Yang L
title	Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence
title_short	Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence
title_full	Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence
title_fullStr	Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence
title_full_unstemmed	Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence
title_sort	emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/34531008b3f54fa4907d9367c0fc30f9
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Emotional face recognition deficit in amnestic patients with mild cognitive impairment: behavioral and electrophysiological evidence

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