Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram

Abstract The study aimed to evaluate the prognostic significance of preoperative systemic inflammatory biomarkers including albumin to globulin ratio (AGR), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) and establish a nomogram in he...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shuai Wang, Yan Deng, Xiao Yu, Xue-Wen Zhang, Cheng-Long Huo, Zhen-Gang Sun, Hong Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/345a5db7b2014a9bb6d54e5f90c23e87
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:345a5db7b2014a9bb6d54e5f90c23e87
record_format	dspace
spelling	oai:doaj.org-article:345a5db7b2014a9bb6d54e5f90c23e872021-12-02T16:14:56ZPrognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram10.1038/s41598-021-93289-32045-2322https://doaj.org/article/345a5db7b2014a9bb6d54e5f90c23e872021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93289-3https://doaj.org/toc/2045-2322Abstract The study aimed to evaluate the prognostic significance of preoperative systemic inflammatory biomarkers including albumin to globulin ratio (AGR), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) and establish a nomogram in hepatocellular carcinoma (HCC) patients after microwave ablation (MWA). 192 HCC patients receiving MWA as initial therapy from the first ward of hepatobiliary surgery were classified as training cohort. Whereas, 84 patients from the second of hepatobiliary surgery were classified as validation cohort. Kaplan–Meier (KM) method and univariate analyses showed that AGR, NLR, LMR, and PLR were significantly associated with OS in the training cohort. Multivariate analysis including clinicopathologic features screened out independent predictors including ascites, tumor size, cancer embolus, AGR, and PLR. Based on those variables, a nomogram for predicting OS was established. The C-index was 0.794 in the training cohort and 0.772 in the validation cohort. Calibration plots identified the nomogram performed well with an ideal model. Compared with Barcelona Clinic Liver Cancer (BCLC) staging system and simple tumor size, the nomogram showed better predictive ability. Besides, the nomogram discovered the highest diagnostic accuracy in predicting postoperative clinical outcome than the combination of the present models with tumor size. In conclusion, the constructed nomogram could accurately predict individualized survival probability and might support clinician in individual treatment optimization and clinical decision-making.Shuai WangYan DengXiao YuXue-Wen ZhangCheng-Long HuoZhen-Gang SunHong ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuai Wang Yan Deng Xiao Yu Xue-Wen Zhang Cheng-Long Huo Zhen-Gang Sun Hong Chang Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram
description	Abstract The study aimed to evaluate the prognostic significance of preoperative systemic inflammatory biomarkers including albumin to globulin ratio (AGR), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) and establish a nomogram in hepatocellular carcinoma (HCC) patients after microwave ablation (MWA). 192 HCC patients receiving MWA as initial therapy from the first ward of hepatobiliary surgery were classified as training cohort. Whereas, 84 patients from the second of hepatobiliary surgery were classified as validation cohort. Kaplan–Meier (KM) method and univariate analyses showed that AGR, NLR, LMR, and PLR were significantly associated with OS in the training cohort. Multivariate analysis including clinicopathologic features screened out independent predictors including ascites, tumor size, cancer embolus, AGR, and PLR. Based on those variables, a nomogram for predicting OS was established. The C-index was 0.794 in the training cohort and 0.772 in the validation cohort. Calibration plots identified the nomogram performed well with an ideal model. Compared with Barcelona Clinic Liver Cancer (BCLC) staging system and simple tumor size, the nomogram showed better predictive ability. Besides, the nomogram discovered the highest diagnostic accuracy in predicting postoperative clinical outcome than the combination of the present models with tumor size. In conclusion, the constructed nomogram could accurately predict individualized survival probability and might support clinician in individual treatment optimization and clinical decision-making.
format	article
author	Shuai Wang Yan Deng Xiao Yu Xue-Wen Zhang Cheng-Long Huo Zhen-Gang Sun Hong Chang
author_facet	Shuai Wang Yan Deng Xiao Yu Xue-Wen Zhang Cheng-Long Huo Zhen-Gang Sun Hong Chang
author_sort	Shuai Wang
title	Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram
title_short	Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram
title_full	Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram
title_fullStr	Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram
title_full_unstemmed	Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram
title_sort	prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/345a5db7b2014a9bb6d54e5f90c23e87
work_keys_str_mv	AT shuaiwang prognosticsignificanceofpreoperativesystemicinflammatorybiomarkersinpatientswithhepatocellularcarcinomaaftermicrowaveablationandestablishmentofanomogram AT yandeng prognosticsignificanceofpreoperativesystemicinflammatorybiomarkersinpatientswithhepatocellularcarcinomaaftermicrowaveablationandestablishmentofanomogram AT xiaoyu prognosticsignificanceofpreoperativesystemicinflammatorybiomarkersinpatientswithhepatocellularcarcinomaaftermicrowaveablationandestablishmentofanomogram AT xuewenzhang prognosticsignificanceofpreoperativesystemicinflammatorybiomarkersinpatientswithhepatocellularcarcinomaaftermicrowaveablationandestablishmentofanomogram AT chenglonghuo prognosticsignificanceofpreoperativesystemicinflammatorybiomarkersinpatientswithhepatocellularcarcinomaaftermicrowaveablationandestablishmentofanomogram AT zhengangsun prognosticsignificanceofpreoperativesystemicinflammatorybiomarkersinpatientswithhepatocellularcarcinomaaftermicrowaveablationandestablishmentofanomogram AT hongchang prognosticsignificanceofpreoperativesystemicinflammatorybiomarkersinpatientswithhepatocellularcarcinomaaftermicrowaveablationandestablishmentofanomogram
_version_	1718384283433828352

Prognostic significance of preoperative systemic inflammatory biomarkers in patients with hepatocellular carcinoma after microwave ablation and establishment of a nomogram

Ejemplares similares