Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study

Abstract Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects....

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Autores principales:	Raluca Cosgarea, Robert Pollmann, Jusra Sharif, Thomas Schmidt, Ronja Stein, Aura Bodea, Thorsten Auschill, Anton Sculean, Rüdiger Eming, Brandon Greene, Michael Hertl, Nicole Arweiler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/345a7b4913854b3fb77a11804ebac6cf
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spelling	oai:doaj.org-article:345a7b4913854b3fb77a11804ebac6cf2021-12-02T14:06:51ZPhotodynamic therapy in oral lichen planus: A prospective case-controlled pilot study10.1038/s41598-020-58548-92045-2322https://doaj.org/article/345a7b4913854b3fb77a11804ebac6cf2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-58548-9https://doaj.org/toc/2045-2322Abstract Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to determine the clinical and immunological efficacy of photodynamic therapy (PDT) in OLP as an alternative, easy-to-use, safe and non-invasive treatment. Twenty patients with OLP were treated with PDT in a prospective case-controlled pilot-study. PDT was performed on the most extensive oral lesion in 4 sessions (day 1, 3, 7, 14). Peripheral blood and lesional T cells were analysed before (day 1) and after PDT treatment (day 28). PDT led to a statistically significant reduction of clinical parameters (lesion size, ABSIS, Thongprasom-score) and improvement of all evaluated quality-of-life (QOL) items. The clinical improvement was accompanied by a significant decrease of the relative number of CD4+ and CD8+ T cells in mucosal OLP-lesions. Furthermore, CXCL10 plasma levels were decreased and the number of activated peripheral CD4 + CD137+ and CD8 + CD137+ T cells and IL-17-secreting T cells was diminished. PDT treatment in OLP leads to lesion reduction and improvement of QOL, and induces local and systemic anti-inflammatory effects. The study identifies PDT as a novel therapeutic option in OLP.Raluca CosgareaRobert PollmannJusra SharifThomas SchmidtRonja SteinAura BodeaThorsten AuschillAnton SculeanRüdiger EmingBrandon GreeneMichael HertlNicole ArweilerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Raluca Cosgarea Robert Pollmann Jusra Sharif Thomas Schmidt Ronja Stein Aura Bodea Thorsten Auschill Anton Sculean Rüdiger Eming Brandon Greene Michael Hertl Nicole Arweiler Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study
description	Abstract Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to determine the clinical and immunological efficacy of photodynamic therapy (PDT) in OLP as an alternative, easy-to-use, safe and non-invasive treatment. Twenty patients with OLP were treated with PDT in a prospective case-controlled pilot-study. PDT was performed on the most extensive oral lesion in 4 sessions (day 1, 3, 7, 14). Peripheral blood and lesional T cells were analysed before (day 1) and after PDT treatment (day 28). PDT led to a statistically significant reduction of clinical parameters (lesion size, ABSIS, Thongprasom-score) and improvement of all evaluated quality-of-life (QOL) items. The clinical improvement was accompanied by a significant decrease of the relative number of CD4+ and CD8+ T cells in mucosal OLP-lesions. Furthermore, CXCL10 plasma levels were decreased and the number of activated peripheral CD4 + CD137+ and CD8 + CD137+ T cells and IL-17-secreting T cells was diminished. PDT treatment in OLP leads to lesion reduction and improvement of QOL, and induces local and systemic anti-inflammatory effects. The study identifies PDT as a novel therapeutic option in OLP.
format	article
author	Raluca Cosgarea Robert Pollmann Jusra Sharif Thomas Schmidt Ronja Stein Aura Bodea Thorsten Auschill Anton Sculean Rüdiger Eming Brandon Greene Michael Hertl Nicole Arweiler
author_facet	Raluca Cosgarea Robert Pollmann Jusra Sharif Thomas Schmidt Ronja Stein Aura Bodea Thorsten Auschill Anton Sculean Rüdiger Eming Brandon Greene Michael Hertl Nicole Arweiler
author_sort	Raluca Cosgarea
title	Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study
title_short	Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study
title_full	Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study
title_fullStr	Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study
title_full_unstemmed	Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study
title_sort	photodynamic therapy in oral lichen planus: a prospective case-controlled pilot study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/345a7b4913854b3fb77a11804ebac6cf
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Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study

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